Metastasis is a complex, multistep process responsible for> 90% of cancer-related deaths. In
addition to genetic and external environmental factors, the physical interactions of cancer …

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Highlights•Physical cues from the tumor microenvironment strongly affect cancer cell
behavior.•Novel techniques increasingly help to capture those cues in vitro.•Mechanisms for …

As tumor cells metastasize from the primary tumor location to a distant secondary site, they
encounter an array of biologically and physically heterogeneous microenvironments. While …

A cell undergoes many genetic and epigenetic changes as it transitions to malignancy.
Malignant transformation is also accompanied by a progressive loss of tissue homeostasis …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

The role of mechanical properties in cancer disease and inflammation is still
underinvestigated and even ignored in many oncological and immunological reviews. In …

Malignant transformation, though primarily driven by genetic mutations in cells, is also
accompanied by specific changes in cellular and extra-cellular mechanical properties such …

Metastasis causes most cancer-related deaths; however, the efficacy of anti-metastatic drugs
is limited by incomplete understanding of the biological mechanisms that drive metastasis …

Disseminated metastatic cancer cells represent one of the most relevant causes of disease
relapse and associated death for cancer patients, and a therapeutic target of the highest …