El presente artículo trata de hacer un breve repaso sobre la evolución, desarrollo de la
estructura y acción celular de algunos derivados metálicos con actividad anticancerosa. Se …

Since the accidental discovery of the anticancer properties of cisplatin more than half a
century ago, significant efforts by the broad scientific community have been and are currently …

Según la Organización Mundial de la Salud (OMS), el cáncer es la segunda causa de
muerte a nivel global, y casi una de cada seis defunciones en el mundo se debe a esta …

La Química Bioinorgánica ha tenido un importante y continuado desarrollo durante las
últimas décadas y, consecuentemente, un fuerte impacto en diversas áreas de la ciencia y …

While cancer remains a major killer in the developed world, a broad spectrum of novel and
exciting approaches are being developed and tested. The importance of metal compounds …

For more than 100 years metal complexes have been extensively used in therapy and since
the discovery of cisplatin the research in this field has expanded exponentially. The scientific …

In the past, metal-based compounds were widely used in the treatment of disease
conditions, but the lack of clear distinction between the therapeutic and toxic doses was a …

Metal-based drugs like Cisplatin are still the most widely employed therapeutics in the
treatment of cancer. Nevertheless, due to their severe drawbacks, such as extended toxicity …

The advent of the clinically approved drug cisplatin started a new era in the design of
metallodrugs for cancer chemotherapy. However, to date, there has not been much success …

The discovery of cis-platin in the treatment of cancer there has been a considerable
exploration on the antitumoral activity of other transition metal complexes. One of the main …