[HTML][HTML] Curcumin regulates autophagy through SIRT3-SOD2-ROS signaling pathway to improve quadriceps femoris muscle atrophy in KOA rat model

H Ye, Y Long, JM Yang, YL Wu, LY Dong, YB Zhong… - Scientific Reports, 2024 - nature.com
Knee osteoarthritis (KOA) usually leads to quadriceps femoris atrophy, which in turn can
further aggravate the progression of KOA. Curcumin (CUR) has anti-inflammatory and …

Curcumin improves age-related and surgically induced osteoarthritis by promoting autophagy in mice

G Zhang, J Cao, E Yang, B Liang, J Ding… - Bioscience …, 2018 - portlandpress.com
Reduced autophagy has been implied in chondrocyte death and osteoarthritis. Curcumin
(Cur) owns therapeutic effect against osteoarthritis (OA) and enhances autophagy in various …

[HTML][HTML] Curcumin inhibits apoptosis of chondrocytes through activation ERK1/2 signaling pathways induced autophagy

X Li, K Feng, J Li, D Yu, Q Fan, T Tang, X Yao, X Wang - Nutrients, 2017 - mdpi.com
Osteoarthritis (OA) is an inflammatory disease of load-bearing synovial joints that is currently
treated with drugs that exhibit numerous side effects and are only temporarily effective in …

The Combination Treatment of Curcumin and Probucol Protects Chondrocytes from TNF‐α Induced Inflammation by Enhancing Autophagy and Reducing Apoptosis …

G Han, Y Zhang, H Li - Oxidative Medicine and Cellular …, 2021 - Wiley Online Library
Osteoarthritis (OA) is a chronic joint disease characterized by cholesterol accumulation in
chondrocytes, cartilage degeneration, as well as extracellular matrix (ECM) destruction, and …

[HTML][HTML] Curcumin ameliorates H2O2‑induced inflammatory response in chondrocytes by inducing autophagy activation

HL Qi, ZY Chen, YH Qin, YZ Li - Experimental and …, 2022 - spandidos-publications.com
Relapsing polychondritis (RP) is a clinical disease characterized by inflammation of
cartilage tissue and chondrocytes. The principal curcuminoid curcumin is the most active …

Curcumin ameliorates IL‐1β‐induced apoptosis by activating autophagy and inhibiting the NF‐κB signaling pathway in rat primary articular chondrocytes

T Chen, R Zhou, Y Chen, W Fu, X Wei… - Cell Biology …, 2021 - Wiley Online Library
Articular cartilage damage and chondrocyte apoptosis are common features of rheumatoid
arthritis and osteoarthritis. Recently, curcumin has been reported to exhibit protective effects …

JAK2/STAT3 signal pathway mediating curcumin in cartilage cell metabolism of osteoarthritis

XS Li, H Chen, P Zhen, SS Li, SH Zhou… - Zhongguo gu Shang …, 2016 - europepmc.org
Objective To observe influence of JAK2/STAT3 signal pathway mediating curcumin in
cartilage cell metabolism of osteoarthritis and mitochondria oxidative stress resistance; also …

[HTML][HTML] Combination of curcumin and catalase protects against chondrocyte injury and knee osteoarthritis progression by suppressing oxidative stress

B Chen, Q He, C Chen, Y Lin, J Xiao, Z Pan, M Li… - Biomedicine & …, 2023 - Elsevier
Knee Osteoarthritis (KOA) is an age-related progressive degenerative joint disease, which is
featured with pain, joint deformity, and disability. Accumulating evidence indicated oxidative …

[HTML][HTML] Curcumin exerts chondroprotective effects against osteoarthritis by promoting AMPK/PINK1/Parkin-mediated mitophagy

Z Jin, B Chang, Y Wei, Y Yang, H Zhang, J Liu… - Biomedicine & …, 2022 - Elsevier
Osteoarthritis (OA), a chronic degenerative disease with heterogeneous properties, is
difficult to cure due to its complex pathogenesis. Curcumin possesses excellent anti …

Curcumin ameliorates skeletal muscle atrophy in type 1 diabetic mice by inhibiting protein ubiquitination

T Ono, S Takada, S Kinugawa… - Experimental …, 2015 - Wiley Online Library
New Findings What is the central question of this study? We sought to examine whether
curcumin could ameliorate skeletal muscle atrophy in diabetic mice by inhibiting protein …