A laser photolysis technique has been developed to assess the quantitative significance of
the delay time of hemoglobin S gelation to the pathophysiology of sickle cell disease …

Kinetic studies on solutions of purified haemoglobin S indicate that the rate of intracellular
polymerization is an important variable in the pathophysiology of sickle cell disease1–4 …

Polymerization of certain Page 1 symposium on Assessment of Radioactive Body Burdens in
Man, Heidelberg, Germany, 11-16 May 1964 (International Atomic Energy Agency, in press). 4 …

KINETIC studies on haemoglobin S gelation have shown that following initiation of the
reaction there is a pronounced delay before the appearance of the polymer1–5. The delay …

Direct analyses of solid phase formed by deoxygenating solutions of sickle-cell hemoglobin
(Hb S) in the presence of certain other hemoglobin species show that hemoglobins A and C …

We report the results of a kinetic investigation on the gelation of purified deoxyhemoglobin
S. Gelation was induced by raising the temperature and was monitored by measuring both …

THE transformation of erythrocytes containing haemoglobin (Hb) S from pliable biconcave
disks into rigid pointed “sickled” forms, which underlies the pathology of sickle cell disease …

To determine the extent to which the broad distribution in intracellular hemoglobin
concentrations found in sickle erythrocytes affects the extent of intracellular polymerization of …

Using a combination of laser photolysis and temperature-jump techniques, the kinetics of
hemoglobin S polymerization have been studied over a wide range of delay times (10− 3 to …

The polymerization and depolymerization of concentrated solutions of sickle cell
deoxyhemoglobin were initiated by raising and lowering the temperature, and the time …