The effect of metformin on indomethacin-induced gastric ulcer: Involvement of nitric oxide/Rho kinase pathway

EY AbdelAziz, MG Tadros, ET Menze - European Journal of Pharmacology, 2021 - Elsevier
Gastric ulcer is a very common disease that represent an economic burden. Non-steroidal
anti-inflammatory drugs induce ulcer in old patients and in patients with comorbidities …

[HTML][HTML] The effect of metformin on ethanol-and indomethacin-induced gastric ulcers in rats

BE İpek, M Yüksel, A Cumbul, F Ercan… - The Turkish Journal …, 2022 - ncbi.nlm.nih.gov
Background: Previous studies found metformin as an effective agent to suppress oxidative
stress, inflammation, and apoptosis in various inflammatory diseases. The present study …

Gastroprotective effects of amtolmetin guacyl: a new non-steroidal anti-inflammatory drug that activates inducible gastric nitric oxide synthase

G Coruzzi, G Coppelli, S Spaggiari… - Digestive and Liver …, 2002 - Elsevier
Background. The novel non-steroidal anti-inflammatory drug amtolmetin guacyl has been
shown to possess markedly reduced ulcerogenic effects and nitric oxide-mediated …

Characterization of mechanisms underlying the effects of esomeprazole on the impairment of gastric ulcer healing with addition of NSAID treatment

R Colucci, M Fornai, L Antonioli, N Ghisu… - Digestive and Liver …, 2009 - Elsevier
BACKGROUND: The efficacy of proton pump inhibitors in patients at high risk of
gastrointestinal injury receiving non-steroidal anti-inflammatory drugs is currently debated …

Effects of leminoprazole, omeprazole and sucralfate on indomethacininduced delayed healing of kissing gastric ulcers in rats

Y Tsukimi, C Nozue, S Okabe - Journal of gastroenterology and …, 1996 - Wiley Online Library
We have examined whether or not repeated treatment with indomethacin delays the healing
of kissing gastric ulcers induced in rats. The effects of leminoprazole, omeprazole and …

A comparative study on the possible protective effect of esomeprazole, spirulina, wheatgrass on indomethacin-induced gastric ulcer in male albino rats

AF Boushra, AM Elsayed, NA Ibrahim… - Molecular Biology …, 2019 - Springer
Gastric ulcer is a common problem affecting the gastrointestinal tract. Spirulina and
wheatgrass are natural substances that have anti-inflammatory and antioxidant effects. The …

The effects of some nonsteroidal anti-inflammatory drugs on experimental induced gastric ulcers in rats

OS Batu, K Erol - Inflammopharmacology, 2007 - Springer
Celecoxib is a frequently used nonsteroidal anti-inflammatory drug (NSAID) in the treatment
of rheumatoid arthritis and osteoarthritis. It selectively inhibits cyclooxygenase II (COX-2) …

[HTML][HTML] Protective effects of ginger and marshmallow extracts on indomethacin-induced peptic ulcer in rats

SS Zaghlool, BA Shehata, AA Abo-Seif… - Journal of natural …, 2015 - ncbi.nlm.nih.gov
Background: Gastric ulcer is one of the most serious diseases. Most classic treatment lines
produce adverse drug reactions. Therefore, this study aimed to investigate the protective …

Involvement of nitric oxide pathway in the anti-inflammatory effect of modafinil on indomethacin-, stress-, and ethanol-induced gastric mucosal injury in rat

P Dejban, F Eslami, N Rahimi, N Takzare… - European Journal of …, 2020 - Elsevier
Gastric ulcer is a prevalent disease with various etiologies, including non-steroidal anti-
inflammatory drugs (NSAIDs), stress conditions, and alcohol, resulting in an inflammatory …

Protective role of nitric oxide in indomethacin-induced gastric ulceration by a mechanism independent of gastric acid secretion

MM Khattab, MZ Gad, D Abdallah - Pharmacological research, 2001 - Elsevier
Gastric ulceration was induced in rats by ip injection of the non-steroidal anti-inflammatory
drug (NSAID), indomethacin (IND)(30 mg kg− 1). Pyloric ligation was carried out in each …