TRanscription and EXport (TREX) is a conserved multisubunit complex essential for
embryogenesis, organogenesis and cellular differentiation throughout life. By linking …

Over the past few decades, we have learned that eukaryotes have evolved sophisticated
means to coordinate the nuclear export of mRNAs with different steps of gene expression …

The mRNA export complex TREX (TREX) is known to contain Aly, UAP56, Tex1 and the
THO complex, among which UAP56 is required for TREX assembly. Here, we systematically …

The export of mRNA from nucleus to cytoplasm requires the conserved and essential
transcription and export (TREX) complex (THO–UAP56/DDX39B–ALYREF). TREX …

THO/TREX is a conserved eukaryotic complex formed by the core THO complex plus
proteins involved in mRNA metabolism and export such as Sub2 and Yra1. Mutations in any …

Messenger RNA (mRNA) synthesis and export are tightly linked, but the molecular
mechanisms of this coupling are largely unknown. In Saccharomyces cerevisiae, the …

The conserved eukaryotic THO-TREX complex acts at the interface between transcription
and mRNA export and affects transcription-associated recombination. To investigate the …

The essential yeast proteins Yra1 and Sub2 are messenger RNA export factors that have
conserved counterparts in metazoans, designated Aly and UAP56, respectively,,,,,,. These …

Coupling of transcription with mRNA processing and export has been shown to be relevant
to efficient gene expression. A number of studies have determined that THO/TREX, a …

The major DNA-specific 3′–5′ exonuclease of mammalian cells is TREX1 (3′ repair
exonuclease 1; previously called DNase III). The human enzyme is encoded by a single …