Alpha-radiotherapy is an internal radiation therapy based on the use of α-particle emitters.
These radionuclides are highly cytotoxic and altogether their characteristics make them of …

α-Particle irradiation of cancerous tissue is increasingly recognized as a potent therapeutic
option. We briefly review the physics, radiobiology, and dosimetry of α-particle emitters, as …

Alpha-radioimmunotherapy (alpha-RIT) is an internal conformal radiotherapy at the cellular
level using alpha-particle emitting radionuclides. Alpha-particles have a very short range in …

Alpha-emitter radiopharmaceutical therapy (α-RPT) is a treatment modality that is
impervious to conventional cellular resistance mechanisms because of the unique …

Background Diffusing alpha emitters radiation therapy (DaRT) utilizes Ra-224 loaded seeds
that continuously release alpha-emitting atoms inside the tumor. 1 The treatment effectively …

Abstract [eng] Targeted alpha therapy (TAT) shows promising results for precise and
selective radiotherapy with effective cancer treatment and minimal toxicity. Alpha particle …

Targeted alpha therapy (TAT) using alpha particle-emitting radionuclides is in the spotlight
after the approval of 223RaCl2 for patients with metastatic castration-resistant prostate …

Among radionuclides usable for tumor therapy, α-particle emitters are characterized by a
very high linear energy transfer (LET) resulting in a larger number of ionizations in a range …

Radiopharmaceuticals are rapidly developing as a field, with the successful use of targeted
beta emitters in neuroendocrine tumors and prostate cancer serving as catalysts. Targeted …

A utilização de radionuclídeos que emitem partículas alfa ocorre desde a sua aprovação
clínica em 2013, com diferentes graus de sucesso. Apesar da sua utilidade clínica, pouco se …