Genetic alterations in the ink4a/arf locus: effects on melanoma development and progression
Genetic alterations in the INK4a/ARF (or CDKN2A) locus have been reported in many
cancer types, including melanoma; head and neck squamous cell carcinomas; lung, breast …
cancer types, including melanoma; head and neck squamous cell carcinomas; lung, breast …
Involvement of the INK4a-ARF locus in genetic predisposition to familial melanoma and in skin carcinogenesis
N Soufir, N Basset-Seguin - Bulletin du Cancer, 2001 - jle.com
The INK4a-ARF locus, localized on 9p21, encodes two tumor suppressor proteins,
p16INK4a and p14ARF, acting respectively through the CDK4-pRb and the p53 pathways …
p16INK4a and p14ARF, acting respectively through the CDK4-pRb and the p53 pathways …
Predicting functional significance of cancer‐associated p16INK4a mutations in CDKN2A
HA McKenzie, C Fung, TM Becker, M Irvine… - Human …, 2010 - Wiley Online Library
Inherited mutations affecting the INK4a/ARF locus (CDKN2A) are associated with melanoma
susceptibility in 40% of multiple case melanoma families. Over 60 different germline …
susceptibility in 40% of multiple case melanoma families. Over 60 different germline …
Mutations in the INK4a/ARF melanoma susceptibility locus functionally impair p14ARF
The INK4a/ARF locus encodes two cell cycle regulatory proteins, the cyclin-dependent
kinase inhibitor, p16 INK4a, and the p53 activator, p14 ARF. Germline mutations in this locus …
kinase inhibitor, p16 INK4a, and the p53 activator, p14 ARF. Germline mutations in this locus …
CDKN2A point mutations D153spl (c. 457G> T) and IVS2+ 1G> T result in aberrant splice products affecting both p16INK4a and p14ARF
JL Rutter, AM Goldstein, MR Davila, MA Tucker… - Oncogene, 2003 - nature.com
The CDKN2A gene, which encodes the proteins p16 INK4a and p14 ARF, is located on
chromosome 9p21. Germline mutations at this locus increase susceptibility to cutaneous …
chromosome 9p21. Germline mutations at this locus increase susceptibility to cutaneous …
The INK4a/ARF locus and melanoma
NE Sharpless, L Chin - Oncogene, 2003 - nature.com
Inactivation of the INK4a/ARF (or CDKN2a) locus is a common and critical genetic event in
the development of human and mouse melanoma. This locus engages the Rb and p53 …
the development of human and mouse melanoma. This locus engages the Rb and p53 …
[HTML][HTML] CDKN2a/p16INK4a mutations and lack of p19ARF involvement in familial melanoma kindreds
MC Fargnoli, S Chimenti, K Peris, G Keller… - Journal of investigative …, 1998 - Elsevier
Germline mutations in the cyclin-dependent kinase inhibitor 2a (CDKN2a) gene, which
maps to the 9p21 chromosomal region and encodes the cyclin-dependent kinase inhibitor …
maps to the 9p21 chromosomal region and encodes the cyclin-dependent kinase inhibitor …
[PDF][PDF] Advances in malignant melanoma: genetic insights from mouse and man
O Kabbarah, L Chin - Front Biosci, 2006 - article.imrpress.com
[Frontiers in Bioscience 11, 928-942, January 1, 2006] 928 Advances in malignant melanoma:
genetic insights from mouse and man O Page 1 [Frontiers in Bioscience 11, 928-942, January …
genetic insights from mouse and man O Page 1 [Frontiers in Bioscience 11, 928-942, January …
CDKN2A germline alterations and the relevance of genotype-phenotype associations in cancer predisposition
Although CDKN2A is well-known as a susceptibility gene for melanoma and pancreatic
cancer, germline variants have also been anecdotally associated with a broader range of …
cancer, germline variants have also been anecdotally associated with a broader range of …
Functional impairment of p16INK4A due to CDKN2A p. Gly23Asp missense mutation
MC Scaini, E Rossi, PLA de Siqueira Torres… - Mutation Research …, 2009 - Elsevier
The CDKN2A locus encodes for two distinct tumor suppressor proteins, p16INK4A and
p14ARF, involved in cell cycle regulation. CDKN2A germline mutations have been …
p14ARF, involved in cell cycle regulation. CDKN2A germline mutations have been …