Alzheimer's disease (AD) is marked by the presence of extracellular amyloid beta (Aβ)
plaques, intracellular neurofibrillary tangles (NFTs) and gliosis, activated glial cells, in the …

The past several decades have given rise to more insights into the role of astrocytes in
normal brain function and diseases. Astrocytes elicit an effect which may be neuroprotective …

Background β-Amyloid (Aβ) plays a central role in Alzheimer's disease (AD) pathogenesis.
Neurons are major sources of Aβ in the brain. However, astrocytes outnumber neurons by at …

Amyloid-β (Aβ) pathology is known to promote chronic inflammatory responses in the brain.
It was thought previously that Aβ is only associated with Alzheimer's disease and Down …

Alzheimer's disease (AD) is a neurodegenerative disease with major clinical hallmarks of
memory loss, dementia, and cognitive impairment. Neuroinflammation is involved in the …

Alzheimer disease (AD) is a frequent and devastating neurodegenerative disease in
humans, but still no curative treatment has been developed. Although many explicative …

Neurons, but not astrocytes, are known as the major source of Aβ, because astrocytes
express low levels of putative β-secretase (BACE). Astrocytes near senile plaque cores …

A growing body of research suggests that astrocytes play roles as contributors to the
pathophysiology of Alzheimer's disease (AD). Several lines of evidence propose that …

Increased production of amyloid β-peptide (Aβ) and altered processing of tau in Alzheimer's
disease (AD) are associated with synaptic dysfunction, neuronal death and cognitive and …

Background: Alzheimer's disease (AD) is a complex neurodegenerative disorder
characterized by the progressive loss of neurons, which typically leads to severe …