[HTML][HTML] Cell death pathways in pathogenic trypanosomatids: lessons of (over) kill

RFS Menna-Barreto - Cell death & disease, 2019 - nature.com
Especially in tropical and developing countries, the clinically relevant protozoa
Trypanosoma cruzi (Chagas disease), Trypanosoma brucei (sleeping sickness) and …

[HTML][HTML] Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death

D Smirlis, M Duszenko, AJ Ruiz, E Scoulica… - Parasites & vectors, 2010 - Springer
Apoptosis is a normal component of the development and health of multicellular organisms.
However, apoptosis is now considered a prerogative of unicellular organisms, including the …

Programmed cell death in trypanosomatids: a way to maximize their biological fitness?

PA Nguewa, MA Fuertes, B Valladares, C Alonso… - Trends in …, 2004 - cell.com
Programmed cell death (PCD) is a biochemical process that plays an essential role in the
development of multicellular organisms. However, accumulating evidence indicates that …

Death of a trypanosome: a selfish altruism

M Duszenko, K Figarella, ET Macleod, SC Welburn - Trends in parasitology, 2006 - cell.com
African trypanosomes and some related parasitic protozoa are affected by a form of
programmed cell death (PCD) that shows typical hallmarks of apoptosis. Although it has …

[HTML][HTML] Impact of protozoan cell death on parasite-host interactions and pathogenesis

CGK Lüder, J Campos-Salinas, E Gonzalez-Rey… - Parasites & vectors, 2010 - Springer
PCD in protozoan parasites has emerged as a fascinating field of parasite biology. This not
only relates to the underlying mechanisms and their evolutionary implications but also to the …

Programmed cell death in trypanosomatids and other unicellular organisms

A Debrabant, N Lee, S Bertholet, R Duncan… - International journal for …, 2003 - Elsevier
In multicellular organisms, cellular growth and development can be controlled by
programmed cell death (PCD), which is defined by a sequence of regulated events …

Biology of human pathogenic trypanosomatids: epidemiology, lifecycle and ultrastructure

JCF Rodrigues, JLP Godinho, W De Souza - Proteins and Proteomics of …, 2013 - Springer
Leishmania and Trypanosoma belong to the Trypanosomatidae family and cause important
human infections such as leishmaniasis, Chagas disease, and sleeping sickness …

[HTML][HTML] Unveiling the intracellular survival gene kit of trypanosomatid parasites

DC Bartholomeu, RMC de Paiva, TAO Mendes… - PLoS …, 2014 - journals.plos.org
Trypanosomatids are unicellular protozoans of medical and economical relevance since
they are the etiologic agents of infectious diseases in humans as well as livestock. Whereas …

Natural programmed cell death in T. cruzi epimastigotes maintained in axenic cultures

V Jimenez, R Paredes, MA Sosa… - Journal of cellular …, 2008 - Wiley Online Library
Trypanosoma cruzi, a parasitic protozoan, is the agent of Chagas' disease or American
trypanosomiasis, an endemic pathology in Latin America, affecting up to 18 million people …

[HTML][HTML] Evolution of apoptosis-like programmed cell death in unicellular protozoan parasites

S Kaczanowski, M Sajid, SE Reece - Parasites & vectors, 2011 - Springer
Apoptosis-like programmed cell death (PCD) has recently been described in multiple taxa of
unicellular protists, including the protozoan parasites Plasmodium, Trypanosoma and …