Bone healing involves complex processes including inflammation, induction, and
remodeling. In this context, anti-inflammatory and osteoconductive multi-functional …

Background Bone tissue regeneration is regulated by complex events, including
inflammation, osteoinduction, and remodeling. Therefore, to induce the complete restoration …

Stem cell-based bone repair in vivo relies on both the osteogenic differentiation of stem cells
and the immune activities of immune cells. The lack of effective means to simultaneously …

In the current study, we fabricated tannic acid-alendronate (TA-ALN) nanocomplexes (NPXs)
via self-assembly. These TA-ALNs were characterized by dynamic light scattering, zeta …

Osteoimmunomodulation was identified as a new and important strategy to enhance
osteogenic differentiation together with other osteogenic approaches. However, approaches …

Current major obstacles for translating the nanoparticle (NP) morphology-related function
into therapeutic purposes come from the challenges in understanding the mechanisms that …

The introduction of nanoparticles into bone tissue engineering strategies is beneficial to
govern cell fate into osteogenesis and the regeneration of large bone defects. The present …

The development of functional materials for osteoporosis is ultimately required for bone
remodeling. However, grafts were accompanied by increasing pro-inflammatory cytokines …

Extensive bone defect repair remains a clinical challenge, since ideal implantable scaffolds
require the integration of excellent biocompatibility, sufficient mechanical strength and high …

Critical-size bone defects are an important problem in clinical practice, which usually occurs
in severe trauma, or tumor resection, and cannot heal completely and autonomously …