Previous studies showed that the cerebrovasodilation response to hypercapnia is
attenuated with aging. The purpose of this study was to determine if normal aging attenuates …

INTRODUCTION: Reports indicate that brain regulation of oxygenation is inhibited in
patients with low baseline oxyhemoglobin concentrations and that brain oxyhemoglobin …

Near infrared spectroscopy (NIRS) is an optical technique that provides information on
cerebral tissue oxygenation and hemodynamics on a continuous, direct, and noninvasive …

The effect of moderately extended, intermittent-hypoxia (IH) on cerebral perfusion during
changes in CO2 was unknown. Thus, we assessed the changes in cerebral vascular …

The relationship between measurements of cerebral blood oxygenation and neuronal
activity is highly complex and depends on both neurovascular and neurometabolic …

The effect of hypercapnia on cerebral metabolic rate of oxygen consumption (CMRO 2) has
been a subject of intensive investigation and debate. Most applications of hypercapnia are …

INTRODUCTION: It has been demonstrated that the cerebrovascular response to hypoxia is
blunted following 10 d of intermittent hypoxia (IH) in healthy humans. The purpose of this …

Background The impact of aging on cerebrovascular function and tissue oxygenation during
graded hypoxemia is incompletely known. This study compared the age effect on these …

Hypoxia increases cerebral blood flow (CBF), but it is unknown whether this increase is
uniform across all brain regions. We used H215O positron emission tomography imaging to …

Cerebral blood flow (CBF) increases from rest to∼ 60% of peak oxygen uptake (VO 2peak)
and thereafter decreases towards baseline due to hyperventilation-induced hypocapnia and …