Macrophage Smad3 protects the infarcted heart, stimulating phagocytosis and regulating inflammation
Rationale: TGF (transforming growth factor)-β is critically involved in myocardial injury,
repair, and fibrosis, activating both Smad (small mothers against decapentaplegic) …
repair, and fibrosis, activating both Smad (small mothers against decapentaplegic) …
Opposing actions of fibroblast and cardiomyocyte Smad3 signaling in the infarcted myocardium
Background: Transforming growth factor–βs regulate a wide range of cellular responses by
activating Smad-dependent and Smad-independent cascades. In the infarcted heart, Smad3 …
activating Smad-dependent and Smad-independent cascades. In the infarcted heart, Smad3 …
Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling
M Bujak, G Ren, HJ Kweon, M Dobaczewski, A Reddy… - Circulation, 2007 - Am Heart Assoc
Background—Postinfarction cardiac repair is regulated through timely activation and
repression of inflammatory pathways, followed by transition to fibrous tissue deposition and …
repression of inflammatory pathways, followed by transition to fibrous tissue deposition and …
Distinct roles of myofibroblast-specific Smad2 and Smad3 signaling in repair and remodeling of the infarcted heart
TGF-βs regulate fibroblast responses, by activating Smad2 or Smad3 signaling, or via Smad-
independent pathways. We have previously demonstrated that myofibroblast-specific …
independent pathways. We have previously demonstrated that myofibroblast-specific …
Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction
M Dobaczewski, M Bujak, N Li… - Circulation …, 2010 - Am Heart Assoc
Rationale: Cardiac fibroblasts are key effector cells in the pathogenesis of cardiac fibrosis.
Transforming growth factor (TGF)-β/Smad3 signaling is activated in the border zone of …
Transforming growth factor (TGF)-β/Smad3 signaling is activated in the border zone of …
Smad1 protects cardiomyocytes from ischemia-reperfusion injury
M Masaki, M Izumi, Y Oshima, Y Nakaoka, T Kuroda… - Circulation, 2005 - Am Heart Assoc
Background—We previously reported that bone morphogenetic protein 2 (BMP2) protected
against apoptosis of serum-deprived cardiomyocytes via induction of Bcl-xL through the …
against apoptosis of serum-deprived cardiomyocytes via induction of Bcl-xL through the …
[HTML][HTML] Smad7 effects on TGF-β and ErbB2 restrain myofibroblast activation and protect from postinfarction heart failure
Repair of the infarcted heart requires TGF-β/Smad3 signaling in cardiac myofibroblasts.
However, TGF-β–driven myofibroblast activation needs to be tightly regulated in order to …
However, TGF-β–driven myofibroblast activation needs to be tightly regulated in order to …
Cardiomyocyte SMAD4-dependent TGF-β signaling is essential to maintain adult heart homeostasis
The role of the transforming growth factor (TGF)-β pathway in myocardial fibrosis is well
recognized. However, the precise role of this signaling axis in cardiomyocyte (CM) biology is …
recognized. However, the precise role of this signaling axis in cardiomyocyte (CM) biology is …
Decreased Smad 7 expression contributes to cardiac fibrosis in the infarcted rat heart
B Wang, J Hao, SC Jones, MS Yee… - American Journal …, 2002 - journals.physiology.org
We examined the role of the transforming growth factor (TGF)-β1 signaling inhibitor Smad 7
in cardiac fibrosis. TGF-β1 (10 ng/ml) was found to increase cytosolic Smad 7 expression in …
in cardiac fibrosis. TGF-β1 (10 ng/ml) was found to increase cytosolic Smad 7 expression in …
[HTML][HTML] The role of Smad2 and Smad3 in regulating homeostatic functions of fibroblasts in vitro and in adult mice
The heart contains an abundant fibroblast population that may play a role in homeostasis, by
maintaining the extracellular matrix (ECM) network, by regulating electrical impulse …
maintaining the extracellular matrix (ECM) network, by regulating electrical impulse …