Hydrolases represent an essential class of enzymes indispensable for the metabolism of
various clinically essential medications. Individuals exhibit marked differences in the …

Introduction: Mammalian carboxylesterase enzymes are a highly conserved metabolic
pathway involved in the metabolism of endogenous and exogenous compounds including …

Carboxylesterase (CES) 1 is the most abundant drug-metabolizing enzyme in human livers,
comprising approximately 1% of the entire liver proteome. CES1 is responsible for 80 …

The carboxylesterase drug hydrolysis pathway has been used extensively to improve the
oral availability of drugs under the assumption that the high capacity and low substrate …

ABSTRACT Introduction Carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are
among the most abundant hydrolases in humans, catalyzing the metabolism of numerous …

Human carboxylesterases 1 and 2 (CES1 and CES2) catalyze the hydrolysis of many
exogenous compounds. Alterations in carboxylesterase sequences could lead to variability …

Carboxylesterase 1 (CES1) is the predominant human hepatic hydrolase responsible for the
metabolism of many clinically important medications. CES1 expression and activity vary …

After the completion of the Human Genome Project, the growing information on the
correlation of drug pharmacokinetics (PK) and pharmacodynamics (PD) with patients' …

The interindividual genetic variations in drug metabolizing enzymes and transporters
influence the efficacy and toxicity of numerous drugs. As a fundamental element in precision …

The pharmacogeneticsof drug-metabolizing enzymes studies the relationship between an
individual's genetic predisposition and ability to metabolize a drug or a foreign compound …