Tumorigenesis is dependent on the reprogramming of cellular metabolism as both direct
and indirect consequence of oncogenic mutations. A common feature of cancer cell …

Cancer cells must rewire cellular metabolism to satisfy the demands of growth and
proliferation. Although many of the metabolic alterations are largely similar to those in …

Tumors reprogram pathways of nutrient acquisition and metabolism to meet the
bioenergetic, biosynthetic, and redox demands of malignant cells. These reprogrammed …

Transformed cells adapt metabolism to support tumor initiation and progression. Specific
metabolic activities can participate directly in the process of transformation or support the …

Cancer is a genetic disease that is caused by mutations in oncogenes, tumor suppressor
genes and stability genes. The fact that the metabolism of tumor cells is altered has been …

Metabolism of cancer cells is geared toward biomass production and proliferation. Since the
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …

The uptake and metabolism of nutrients support fundamental cellular process from
bioenergetics to biomass production and cell fate regulation. While many studies of cell …

Cancer cells exhibit profound metabolic alterations, allowing them to fulfill the metabolic
needs that come with increased proliferation and additional facets of malignancy. Such a …

Cancer metabolism has long been equated with aerobic glycolysis, seen by early
biochemists as primitive and inefficient. Despite these early beliefs, the metabolic signatures …

Background The study of cancer metabolism has been largely dedicated to exploring the
hypothesis that oncogenic transformation rewires cellular metabolism to sustain elevated …