Vascular endothelial growth factor receptors (VEGFRs) are a family of receptor protein
tyrosine kinases that play an important role in the regulation of tumor-induced angiogenesis …

Vascular epidermal growth factor receptor-2 (VEGFR-2), as an important tyrosine
transmembrane protein, plays an important role in regulating endothelial cell proliferation …

Induction of angiogenesis represents one of the major hallmarks of cancer. The growth of
new vessels is crucial to provide malignant cells with an adequate supply of oxygen and …

The vascular endothelial growth factor receptor-1 (VEGFR-1) is a tyrosine kinase receptor
for VEGF-A, VEGF-B, and placental growth factor (PlGF) ligands that is expressed in …

Introduction: Angiogenesis is an important component of certain normal physiological
processes, but aberrant angiogenesis contributes to some pathological disorders and in …

Over the last decade, the concept of targeted biological therapy for the treatment of cancer
has emerged. However, a better understanding of these targets and their role in tumor cells …

Angiogenesis inhibitors have produced significant advances in the treatment of several
tumors including colorectal, lung, ovarian and renal carcinomas. These agents, however …

Despite setbacks, the clinical development of antiangiogenic agents has accelerated
remarkably over the past 3–4 years. Consequently, there are currently three direct inhibitors …

Vascular endothelial growth factor receptor (VEGFR) is a very important receptor tyrosine
kinase (RTK) that can induce angiogenesis, increase cell growth and metastasis, reduce …

Multitargeted agents represent the next generation of targeted therapies in solid tumors. The
benefits of individually targeting the vascular endothelial growth factor receptor (VEGFR) …