Polycyclic polyprenylated acylphloroglucinols

R Ciochina, RB Grossman - Chemical reviews, 2006 - ACS Publications
In recent years, the antidepressant activity of Hypericum perforatum, commonly known as St.
John's wort, has attracted much attention from both scientists1-4 and the wider public. 5 …

Are acylphloroglucinols lead structures for the treatment of degenerative diseases?

L Verotta - Phytochemistry Reviews, 2002 - Springer
In recent years a widespread interest in the antidepressant activity of Hypericum perforatum
L. has attracted much activity in investigating metabolites from the Guttiferae, many of which …

Research progress of polycyclic polyprenylated acylphloroglucinols

XW Yang, RB Grossman, G Xu - Chemical reviews, 2018 - ACS Publications
Polycyclic polyprenylated acylphloroglucinols (PPAPs) are a class of hybrid natural products
sharing the mevalonate/methylerythritol phosphate and polyketide biosynthetic pathways …

Sampsoniones A–M, a unique family of caged polyprenylated benzoylphloroglucinol derivatives, from Hypericum sampsonii

LH Hu, KY Sim - Tetrahedron, 2000 - Elsevier
Further thorough investigation of the ethanolic extract of the aerial parts of Hypericum
sampsonii has yielded sampsoniones K–M which together with the earlier isolated …

Polycyclic Polyprenylated Acylphloroglucinol Congeners Possessing Diverse Structures from Hypericum henryi

XW Yang, MM Li, X Liu, D Ferreira, Y Ding… - Journal of Natural …, 2015 - ACS Publications
Polycyclic polyprenylated acylphloroglucinols (PPAPs) are a class of hybrid natural products
sharing the mevalonate/methylerythritol phosphate and polyketide biosynthetic pathways …

The chemistry of the polycyclic polyprenylated acylphloroglucinols

JA Richard, RH Pouwer… - Angewandte Chemie …, 2012 - Wiley Online Library
With their fascinating biological profiles and stunningly complex molecular architectures, the
polycyclic polyprenylated acylphloroglucinols (PPAPs) have long provided a fertile playing …

Rapid Access to Polyprenylated Phloroglucinols via Alkylative Dearomatization− Annulation: Total Synthesis of (±)-Clusianone

J Qi, JA Porco - Journal of the American Chemical Society, 2007 - ACS Publications
A concise approach to the bicyclo [3.3. 1] nonane framework of the polyprenylated
phloroglucinol natural products utilizing a tandem alkylative dearomatization− annulation …

Hypersubones A and B, New Polycyclic Acylphloroglucinols with Intriguing Adamantane Type Cores from Hypericum subsessile

Y Liao, X Liu, J Yang, YZ Lao, XW Yang, XN Li… - Organic …, 2015 - ACS Publications
Hypersubones A and B (1, 2), two adamantane type polycyclic polyprenylated
acylphloroglucinols possessing an unprecedented seco-adamantane architecture and a …

Synthetic efforts toward [3.3. 1] bridged bicyclic phloroglucinol natural products

JT Njardarson - Tetrahedron, 2011 - Elsevier
The aim of this review is to present a detailed account of all published synthetic approaches
toward the [3.3. 1] bridged bicyclic class of phloroglucinol natural products most famously …

The total synthesis of hyperpapuanone, hyperibone L, epi-clusianone and oblongifolin A

N Biber, K Möws, B Plietker - Nature chemistry, 2011 - nature.com
Polyprenylated polycyclic acylphloroglucines (PPAPs) are a family of natural products that
possess a wide range of different important biological activities because of the relative …