Exosomes and their application in biomedical field: difficulties and advantages

J Rezaie, S Ajezi, ÇB Avci, M Karimipour… - Molecular …, 2018 - Springer
The science of gene therapy has experienced a controversial history. At first, the initial
concept that various disorders become curable by gene transferring was very exciting and …

Exosomes as a nanodelivery system: a key to the future of neuromedicine?

A Aryani, B Denecke - Molecular neurobiology, 2016 - Springer
Since the beginning of the last decade, exosomes have been of increased interest in the
science community. Exosomes represent a new kind of long distance transfer of biological …

Exosomes: a new weapon to treat the central nervous system

L Braccioli, C Van Velthoven, CJ Heijnen - Molecular neurobiology, 2014 - Springer
The potential of exosomes to treat central nervous system (CNS) pathologies has been
recently demonstrated. These studies make way for a complete new field that aims to exploit …

Exosomes: structure, biogenesis, types and application in diagnosis and gene and drug delivery

S Agarwal, V Agarwal, M Agarwal… - Current Gene …, 2020 - ingentaconnect.com
In recent times, several approaches for targeted gene therapy (GT) had been studied.
However, the emergence of extracellular vesicles (EVs) as a shuttle carrying genetic …

Exosomes: natural nanoparticles as bio shuttles for RNAi delivery

SG Darband, M Mirza-Aghazadeh-Attari… - Journal of controlled …, 2018 - Elsevier
Application of exosomes, natural nanoscale vesicles, as specific delivery vehicles has
received considerable attention in recent past years. The presence of various adhesive …

Exosomes as novel bio-carriers for gene and drug delivery

XC Jiang, JQ Gao - International journal of pharmaceutics, 2017 - Elsevier
Clinical treatments have stalled in certain diseases due to a lack of proper therapeutic
delivery systems. Recent studies have identified exosomes for their potential use as cell-free …

Exosomes: promising delivery tools for overcoming blood-brain barrier and glioblastoma therapy

SH Khatami, N Karami, M Taheri-Anganeh… - Molecular …, 2023 - Springer
Gliomas make up virtually 80% of all lethal primary brain tumors and are categorized based
on their cell of origin. Glioblastoma is an astrocytic tumor that has an inferior prognosis …

Exosomes and the emerging field of exosome-based gene therapy

AJ O'Loughlin, CA Woffindale… - Current gene …, 2012 - ingentaconnect.com
Exosomes are a subtype of membrane vesicle released from the endocytic compartment of
live cells. They play an important role in endogenous cell-to-cell communication. Previously …

Exosomes as nano-theranostic delivery platforms for gene therapy

A Tan, J Rajadas, AM Seifalian - Advanced Drug Delivery Reviews, 2013 - Elsevier
Exosomes are biological membrane vesicles measuring 30 to 100nm. They contain an
abundance of small molecules like tetraspanins, receptors for targeting and adhesion, lipids …

Exosomes in brain diseases: pathogenesis and therapeutic targets

Q Si, L Wu, D Pang, P Jiang - MedComm, 2023 - Wiley Online Library
Exosomes are extracellular vesicles with diameters of about 100 nm that are naturally
secreted by cells into body fluids. They are derived from endosomes and are wrapped in …