Proteins are the main targets of most drugs; however, system-wide methods to monitor
protein activity and function are still underused in drug discovery. Novel biochemical …

Chemoproteomics represents a new research discipline at the interface of medicinal
chemistry, biochemistry, and cell biology focused on studying the molecular mechanisms of …

The (poly-) pharmacological activities of a drug can only be understood if its interactions with
cellular components are comprehensively characterized. Mass spectrometry-based …

Preclinical stages in the drug discovery process require a multitude of biochemical and
genetic assays in order to characterize the effects of drug candidates on cellular systems …

Creating first-in-class medications to treat human disease is an extremely challenging
endeavor. While genome sequencing and genetics are making direct connections between …

Mass spectrometry offers the potential of acquiring high resolution data depicting the
functional status of a group of healthy or diseased individuals, according to different …

Recent advances in the biological and analytical sciences have led to unprecedented
interest in the discoveryand quantitation of endogenous molecules that serve as indicators …

Research into the basic biology of human health and disease, as well as translational
human research and clinical applications, all benefit from the growing accessibility and …

Proteomics is a new enabling technology that is being integrated into the drug discovery
process. This will facilitate the systematic analysis of proteins across any biological system …

Highlights•Developing inhibitors against undruggable proteins has remained
challenging.•Activity-based protein profiling enables strategies for mapping druggable …