Hev b 6.02 (hevein), identified as a major allergen from natural rubber latex (NRL), is
involved in the latex-fruit syndrome and also acts as a pathogenesis defense-related protein …

Background: Hev b 5 is a potent latex allergen. In this study, we characterize the linear B-cell
epitopes for three monoclonal antibodies (mAbs) to Hev b 5. Methods: The mAbs included 2 …

Of the several latex proteins cloned and expressed, the rubber elongation factor, Hev b 1,
and the closely related Hev b 3, represent two major allergens associated with latex allergy …

Background The rubber elongation factor in Hevea rubber (Hev b 1) is one of the most
important latex allergen and is leading cause oflatex type 1 hypersensitivity in children with …

Background: Hev b 5 is a major latex allergen and potential candidate for an immunotherapy
reagent. Objective: The purpose of this study was to produce a hypoallergenic form of Hev b …

Background: Multiple immunoglobulin E (IgE)‐binding proteins in natural rubber latex
extracts have been identified. In the case of Hev b 6 a differentiation was made between the …

Hevein (Hev b 6.02) is a major IgE-binding allergen in natural rubber latex and
manufactured products. Both tryptophans (Trp21 and Trp23) of the hevein molecule were …

Hev b 6.01 is a major allergen of natural rubber latex with sensitization of 70–86% of latex
glove-allergic subjects. Recently, we mapped the immunodominant T cell sites of Hev b 6.01 …

Background: Hev b 5 is an acidic protein (isoelectric point, 3.5) rich in glutamic acid with 9
repeated amino acid (AA) sequences of XEEX or XEEEX. Although its function in Hevea …

Recently we have established that IgE Abs bind to conformational epitopes in the N-and C-
terminal regions of the major natural rubber latex allergen, hevein (Hev b 6.02). To identify …