Immune dysregulation in amyotrophic lateral sclerosis: mechanisms and emerging therapies

DR Beers, SH Appel - The Lancet Neurology, 2019 - thelancet.com
Neuroinflammation is a common pathological feature of many neurodegenerative diseases,
including amyotrophic lateral sclerosis (ALS), and is characterised by activated CNS …

Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

T Philips, W Robberecht - The Lancet Neurology, 2011 - thelancet.com
Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis (ALS) are characterised by the appearance of reactive …

[HTML][HTML] Peripheral and central nervous system immune response crosstalk in amyotrophic lateral sclerosis

Z Liu, X Cheng, S Zhong, X Zhang, C Liu… - Frontiers in …, 2020 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
muscle weakness due to the degeneration of the upper and lower motor neurons …

Immune-mediated mechanisms in the pathoprogression of amyotrophic lateral sclerosis

W Zhao, DR Beers, SH Appel - Journal of Neuroimmune Pharmacology, 2013 - Springer
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with
selective loss of upper and lower motor neurons. At sites of motor neuron injury …

Amyotrophic lateral sclerosis is a systemic disease: peripheral contributions to inflammation-mediated neurodegeneration

SH Appel, DR Beers, W Zhao - Current Opinion in Neurology, 2021 - journals.lww.com
The collective dysregulation of cells and cytokines in patients with ALS accurately reflect
increased disease burdens, more rapid progression rates and reduced survival times …

Interplay between immunity and amyotrophic lateral sclerosis: Clinical impact

F De Marchi, I Munitic, A Amedei, JD Berry… - Neuroscience & …, 2021 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a debilitating and rapidly fatal neurodegenerative
disease. Despite decades of research and many new insights into disease biology over the …

[HTML][HTML] The peripheral immune system and amyotrophic lateral sclerosis

PA McCombe, JD Lee, TM Woodruff… - Frontiers in …, 2020 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease that is defined by
loss of upper and lower motor neurons, associated with accumulation of protein aggregates …

Immunological drivers of amyotrophic lateral sclerosis

TF Gendron, L Petrucelli - Science translational medicine, 2023 - science.org
Amyotrophic lateral sclerosis (ALS), a devastating motor neuron disease involving complex
genetic and environmental factors, is associated with neuroinflammation. Preclinical and …

Immunity in amyotrophic lateral sclerosis: Blurred lines between excessive inflammation and inefficient immune responses

LC Béland, A Markovinovic, H Jakovac… - Brain …, 2020 - academic.oup.com
Despite wide genetic, environmental and clinical heterogeneity in amyotrophic lateral
sclerosis, a rapidly fatal neurodegenerative disease targeting motoneurons …

[HTML][HTML] T cell responses at diagnosis of amyotrophic lateral sclerosis predict disease progression

S Yazdani, C Seitz, C Cui, A Lovik, L Pan… - Nature …, 2022 - nature.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, involving
neuroinflammation and T cell infiltration in the central nervous system. However, the …