LPA and PLG Sequence Variation and Kringle IV-2 Copy Number in Two Populations

DC Crawford, Z Peng, JF Cheng, D Boffelli, M Ahearn… - Human …, 2008 - karger.com
Abstract Background/Aims: Lp (a) levels have long been recognized as a potential risk factor
for coronary heart disease that is almost completely under genetic control. Much of the …

[HTML][HTML] Single-Nucleotide Polymorphisms in LPA Explain Most of the Ancestry-Specific Variation in Lp(a) Levels in African Americans

RC Deo, JG Wilson, C Xing, K Lawson, WHL Kao… - PloS one, 2011 - journals.plos.org
Lipoprotein (a)(Lp (a)) is an important causal cardiovascular risk factor, with serum Lp (a)
levels predicting atherosclerotic heart disease and genetic determinants of Lp (a) levels …

Genetic variants associated with Lp (a) lipoprotein level and coronary disease

R Clarke, JF Peden, JC Hopewell… - … England Journal of …, 2009 - Mass Medical Soc
Background An increased level of Lp (a) lipoprotein has been identified as a risk factor for
coronary artery disease that is highly heritable. The genetic determinants of the Lp (a) …

Comprehensive Analysis of Genomic Variation in the LPA Locus and Its Relationship to Plasma Lipoprotein(a) in South Asians, Chinese, and European Caucasians

MB Lanktree, SS Anand, S Yusuf… - Circulation …, 2010 - Am Heart Assoc
Background—Functional copy number variation in the apolipoprotein (a) gene (LPA)
underlies a variable number of protein kringle domains repeated in tandem in the lipoprotein …

[HTML][HTML] Prediction of cardiovascular risk by Lp(a) concentrations or genetic variants within the LPA gene region

F Kronenberg - Clinical Research in Cardiology Supplements, 2019 - Springer
In the middle of the 1990s the interest in Lp (a) vanished after a few badly performed studies
almost erased Lp (a) from the map of biological targets. However, since roughly 10 years the …

[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene

S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
Abstract High lipoprotein (a)[Lp (a)] concentrations are one of the most important genetically
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …

[HTML][HTML] Multiple QTL influence the serum Lp (a) concentration: a genome-wide linkage screen in the PROCARDIS study

S Barlera, C Specchia, M Farrall, BD Chiodini… - European journal of …, 2007 - nature.com
The serum concentration of lipoprotein Lp (a) is known to be highly heritable and associated
with cardiovascular risk. A genome-wide variance component linkage analysis was …

Lipoprotein (a): resurrected by genetics

F Kronenberg, G Utermann - Journal of internal medicine, 2013 - Wiley Online Library
Plasma lipoprotein (a)[L p (a)] is a quantitative genetic trait with a very broad and skewed
distribution, which is largely controlled by genetic variants at the LPA locus on chromosome …

Genetic evidence that lipoprotein (a) associates with atherosclerotic stenosis rather than venous thrombosis

PR Kamstrup, A Tybjærg-Hansen… - … , and vascular biology, 2012 - Am Heart Assoc
Objective—The aim of the present study was to determine whether lipoprotein (a)[Lp (a)],
considered a causal risk factor for cardiovascular disease, primarily promotes thrombosis or …

[HTML][HTML] The effect of LPA Thr3888Pro on lipoprotein (a) and coronary artery disease is modified by the LPA KIV-2 variant 4925G> A

R Grüneis, C Lamina, S Di Maio, S Schönherr… - Atherosclerosis, 2022 - Elsevier
Background and aims High lipoprotein (a)[Lp (a)] concentrations are associated with
increased coronary artery disease (CAD) risk. Lp (a) is regulated mainly genetically by the …