LPA and PLG Sequence Variation and Kringle IV-2 Copy Number in Two Populations
Abstract Background/Aims: Lp (a) levels have long been recognized as a potential risk factor
for coronary heart disease that is almost completely under genetic control. Much of the …
for coronary heart disease that is almost completely under genetic control. Much of the …
[HTML][HTML] Single-Nucleotide Polymorphisms in LPA Explain Most of the Ancestry-Specific Variation in Lp(a) Levels in African Americans
Lipoprotein (a)(Lp (a)) is an important causal cardiovascular risk factor, with serum Lp (a)
levels predicting atherosclerotic heart disease and genetic determinants of Lp (a) levels …
levels predicting atherosclerotic heart disease and genetic determinants of Lp (a) levels …
Genetic variants associated with Lp (a) lipoprotein level and coronary disease
R Clarke, JF Peden, JC Hopewell… - … England Journal of …, 2009 - Mass Medical Soc
Background An increased level of Lp (a) lipoprotein has been identified as a risk factor for
coronary artery disease that is highly heritable. The genetic determinants of the Lp (a) …
coronary artery disease that is highly heritable. The genetic determinants of the Lp (a) …
Comprehensive Analysis of Genomic Variation in the LPA Locus and Its Relationship to Plasma Lipoprotein(a) in South Asians, Chinese, and European Caucasians
Background—Functional copy number variation in the apolipoprotein (a) gene (LPA)
underlies a variable number of protein kringle domains repeated in tandem in the lipoprotein …
underlies a variable number of protein kringle domains repeated in tandem in the lipoprotein …
[HTML][HTML] Prediction of cardiovascular risk by Lp(a) concentrations or genetic variants within the LPA gene region
F Kronenberg - Clinical Research in Cardiology Supplements, 2019 - Springer
In the middle of the 1990s the interest in Lp (a) vanished after a few badly performed studies
almost erased Lp (a) from the map of biological targets. However, since roughly 10 years the …
almost erased Lp (a) from the map of biological targets. However, since roughly 10 years the …
[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene
S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
Abstract High lipoprotein (a)[Lp (a)] concentrations are one of the most important genetically
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …
[HTML][HTML] Multiple QTL influence the serum Lp (a) concentration: a genome-wide linkage screen in the PROCARDIS study
S Barlera, C Specchia, M Farrall, BD Chiodini… - European journal of …, 2007 - nature.com
The serum concentration of lipoprotein Lp (a) is known to be highly heritable and associated
with cardiovascular risk. A genome-wide variance component linkage analysis was …
with cardiovascular risk. A genome-wide variance component linkage analysis was …
Lipoprotein (a): resurrected by genetics
F Kronenberg, G Utermann - Journal of internal medicine, 2013 - Wiley Online Library
Plasma lipoprotein (a)[L p (a)] is a quantitative genetic trait with a very broad and skewed
distribution, which is largely controlled by genetic variants at the LPA locus on chromosome …
distribution, which is largely controlled by genetic variants at the LPA locus on chromosome …
Genetic evidence that lipoprotein (a) associates with atherosclerotic stenosis rather than venous thrombosis
PR Kamstrup, A Tybjærg-Hansen… - … , and vascular biology, 2012 - Am Heart Assoc
Objective—The aim of the present study was to determine whether lipoprotein (a)[Lp (a)],
considered a causal risk factor for cardiovascular disease, primarily promotes thrombosis or …
considered a causal risk factor for cardiovascular disease, primarily promotes thrombosis or …
[HTML][HTML] The effect of LPA Thr3888Pro on lipoprotein (a) and coronary artery disease is modified by the LPA KIV-2 variant 4925G> A
R Grüneis, C Lamina, S Di Maio, S Schönherr… - Atherosclerosis, 2022 - Elsevier
Background and aims High lipoprotein (a)[Lp (a)] concentrations are associated with
increased coronary artery disease (CAD) risk. Lp (a) is regulated mainly genetically by the …
increased coronary artery disease (CAD) risk. Lp (a) is regulated mainly genetically by the …