Neuroimaging in hereditary spastic paraplegias: from qualitative cues to precision biomarkers
G Mulkerrin, MC França Jr, J Lope… - Expert review of …, 2022 - Taylor & Francis
Introduction Hereditary spastic paraplegias (HSP) include a clinically and genetically
heterogeneous group of conditions. Novel imaging modalities have been increasingly …
heterogeneous group of conditions. Novel imaging modalities have been increasingly …
[HTML][HTML] Neuroimaging in hereditary spastic paraplegias: current use and future perspectives
FF Da Graca, TJR De Rezende… - Frontiers in …, 2019 - frontiersin.org
Hereditary spastic paraplegias (HSP) are a large group of genetic diseases characterized by
progressive degeneration of the long tracts of the spinal cord, namely the corticospinal tracts …
progressive degeneration of the long tracts of the spinal cord, namely the corticospinal tracts …
[HTML][HTML] Multimodal MRI longitudinal assessment of white and gray matter in different SPG types of hereditary spastic paraparesis
D Montanaro, M Vavla, F Frijia… - Frontiers in …, 2020 - frontiersin.org
Hereditary spastic paraplegias (HSP) are a group of genetically and clinically
heterogeneous neurologic disorders. Hereby we describe a relatively large group of patients …
heterogeneous neurologic disorders. Hereby we describe a relatively large group of patients …
[HTML][HTML] Outcome measures and biomarkers for clinical trials in hereditary spastic paraplegia: a scoping review
Hereditary spastic paraplegia (HSP) is characterized by progressive lower limb spasticity.
There is no disease-modifying treatment currently available. Therefore, standardized …
There is no disease-modifying treatment currently available. Therefore, standardized …
Hereditary spastic paraplegia: beyond clinical phenotypes toward a unified pattern of central nervous system damage
F Agosta, M Scarlato, EG Spinelli, E Canu, S Benedetti… - Radiology, 2015 - pubs.rsna.org
Purpose To investigate whether specific patterns of brain gray matter (GM) regional volumes
and white matter (WM) microstructural abnormalities and spinal cord atrophy occur in …
and white matter (WM) microstructural abnormalities and spinal cord atrophy occur in …
Neuroimaging patterns in paediatric onset hereditary spastic paraplegias
C Dosi, R Pasquariello, C Ticci, G Astrea… - Journal of the …, 2021 - Elsevier
Hereditary spastic paraplegias (HSPs) are a clinically and genetically heterogeneous group
of neurodegenerative disorders characterized by progressive spasticity and weakness of the …
of neurodegenerative disorders characterized by progressive spasticity and weakness of the …
Hereditary spastic paraplegias: time for an objective case definition and a new nosology for neurogenetic disorders to facilitate biomarker/therapeutic studies
LEO Elsayed, IZM Eltazi, AEM Ahmed… - Expert review of …, 2019 - Taylor & Francis
ABSTRACT Introduction: Hereditary spastic paraplegias (HSPs) are heterogeneous
neurodegenerative disorders characterized by progressive lower limb weakness and …
neurodegenerative disorders characterized by progressive lower limb weakness and …
[HTML][HTML] Clinical and paraclinical indicators of motor system impairment in hereditary spastic paraplegia: a pilot study
A Martinuzzi, D Montanaro, M Vavla, G Paparella… - PLoS …, 2016 - journals.plos.org
Background Hereditary spastic paraplegias (HSP) are a composite and genetically
heterogeneous group of conditions mainly expressed by the impairment of the central motor …
heterogeneous group of conditions mainly expressed by the impairment of the central motor …
[HTML][HTML] Next-generation sequencing study reveals the broader variant spectrum of hereditary spastic paraplegia and related phenotypes
E Elert-Dobkowska, I Stepniak, W Krysa… - neurogenetics, 2019 - Springer
Hereditary spastic paraplegias (HSPs) are clinically and genetically heterogeneous
neurodegenerative disorders. Numerous genes linked to HSPs, overlapping phenotypes …
neurodegenerative disorders. Numerous genes linked to HSPs, overlapping phenotypes …
[HTML][HTML] Genetic origin of patients having spastic paraplegia with or without other neurologic manifestations
J Chen, Z Zhao, H Shen, Q Bing, N Li, X Guo, J Hu - BMC neurology, 2022 - Springer
Background Hereditary spastic paraplegia (HSP) is a group of neurodegenerative diseases
characterized by lower-limb spastic paraplegia with highly genetic and clinical …
characterized by lower-limb spastic paraplegia with highly genetic and clinical …