[HTML][HTML] Melatonin ameliorates diquat-induced testicular toxicity via reducing oxidative stress, inhibiting apoptosis, and maintaining the integrity of blood-testis barrier …
L Yang, J Cheng, D Xu, Z Zhang, R Hua, H Chen… - Toxics, 2023 - mdpi.com
Diquat is a fast, potent, and widely used bipyridine herbicide in agriculture and it induces
oxidative stress in several animal models. However, its genotoxic effects on the male …
oxidative stress in several animal models. However, its genotoxic effects on the male …
The protective role of melatonin in citalopram-induced reproductive toxicity via modulating nitro-oxidative stress and apoptosis in male mice
M Moradi, MA Hashemian, E Douhandeh… - Reproductive …, 2023 - Elsevier
Citalopram is the most potent selective serotonin reuptake inhibitor, commonly prescribed as
an antidepressant, which can cause sexual dysfunction. Melatonin is a natural, highly …
an antidepressant, which can cause sexual dysfunction. Melatonin is a natural, highly …
[HTML][HTML] Melatonin protects rats testes against bleomycin, etoposide, and cisplatin-induced toxicity via mitigating nitro-oxidative stress and apoptosis
There is growing concern that some cytotoxic regimens for cancer adversely affect
spermatogenesis and male fertility. Increasing evidence demonstrated that melatonin has …
spermatogenesis and male fertility. Increasing evidence demonstrated that melatonin has …
[HTML][HTML] Diquat causes mouse testis injury through inducing heme oxygenase-1-mediated ferroptosis in spermatogonia
J Cheng, L Yang, Z Zhang, D Xu, R Hua, H Chen… - Ecotoxicology and …, 2024 - Elsevier
Diquat dibromide (DQ) is a globally used herbicide in agriculture, and its overuse poses an
important public health issue, including male reproductive toxicity in mammals. However, the …
important public health issue, including male reproductive toxicity in mammals. However, the …
Protective effects of melatonin on DEHP‐induced apoptosis and oxidative stress in prepubertal testes via the PI3K/AKT pathway
J Chen, T Zhao, X Zheng, L Kang… - Environmental …, 2024 - Wiley Online Library
Abstract Di (2‐ethylhexyl) phthalate (DEHP), an environmental endocrine disruptor, is one of
the most common plasticizers and is widely used in various plastic products. DEHP induces …
the most common plasticizers and is widely used in various plastic products. DEHP induces …
Melatonin ameliorates Bisphenol S induced testicular damages by modulating Nrf‐2/HO‐1 and SIRT‐1/FOXO‐1 expressions
BPS has detrimental effects on human reproductive health and emerged as an
environmental contaminant for global health concern. This study deals with the adverse …
environmental contaminant for global health concern. This study deals with the adverse …
Melatonin alleviates cisplatin-induced mice spermatogenesis defects
Z Peng, WZ Xin, ZY Sheng, T Zi, LY Nan, WZ Lin… - Reproductive …, 2023 - Elsevier
Cisplatin (CDDP) is a chemotherapeutic drug that is used to treat many different types of
tumors. However, it also has significant adverse effects on male reproduction, which are …
tumors. However, it also has significant adverse effects on male reproduction, which are …
MitoQ ameliorates testis injury from oxidative attack by repairing mitochondria and promoting the Keap1-Nrf2 pathway
J Zhang, X Bao, M Zhang, Z Zhu, L Zhou… - Toxicology and applied …, 2019 - Elsevier
Mitochondrial dysfunctions induced by oxidative stress could play a pivotal role in the
development of testicular damage and degeneration, leading to impaired fertility in …
development of testicular damage and degeneration, leading to impaired fertility in …
[HTML][HTML] Melatonin alleviates oxidative stress damage in mouse testes induced by bisphenol A
Q Qi, J Yang, S Li, J Liu, D Xu, G Wang… - Frontiers in Cell and …, 2024 - frontiersin.org
We investigated the effect of melatonin on bisphenol A (BPA)-induced oxidative stress
damage in testicular tissue and Leydig cells. Mice were gavaged with 50 mg/kg BPA for 30 …
damage in testicular tissue and Leydig cells. Mice were gavaged with 50 mg/kg BPA for 30 …
Melatonin alleviates cadmium‐induced cellular stress and germ cell apoptosis in testes
YL Ji, H Wang, C Meng, XF Zhao… - Journal of pineal …, 2012 - Wiley Online Library
Increasing evidence demonstrates that melatonin has an anti‐apoptotic effect in somatic
cells. However, whether melatonin can protect against germ cell apoptosis remains obscure …
cells. However, whether melatonin can protect against germ cell apoptosis remains obscure …
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