This study evaluated the efficacy of a 3-week course of succimer treatment to alleviate
behavioral deficits in rats exposed to lead (Pb) for the first 4 weeks of life. A 3× 2 factorial …

Background There is growing pressure for clinicians to prescribe chelation therapy at only
slightly elevated blood lead levels. However, very few studies have evaluated whether …

This presentation summarizes several of the rodent and non-human studies that we have
conducted to help inform the efficacy and clinical utility of succimer (meso-2, 3 …

The extent to which succimer (meso-2, 3-dimercaptosuccinic acid [DMSA], Chemet) reduces
brain lead (Pb) levels may be a primary consideration in evaluating its efficacy for reducing …

Although many studies have demonstrated the efficacy of succimer chelation in reducing
blood and brain lead levels, the relative efficacy of the drug in the two tissues is less well …

Behavioral disorders involving attention and impulse control dysfunction, such as ADHD, are
among the most prevalent disorders in children and adolescents, with significant impact on …

The extent to which succimer (2, 3-dimercaptosuccinic acid, DMSA) chelation reduces target
organ lead (Pb) levels, including the skeleton, relative to the cessation of Pb exposure is a …

Succimer is considered to be a safe and effective treatment for lead (Pb) poisoning, since it
reduces body Pb levels without an apparent diuresis of other essential elements. However …

A total of 52 nursery-reared monkeys (Macaca fascicularis) were dosed orally with 1, 5
mg/kg/day of lead on one of four dosing regimens (13 monkeys/group): Group 1, vehicle …

Cynomolgus monkeys (Macaca fascicularis) were dosed from birth with 100, 50, or 0
μg/kg/day of lead. This treatment resulted in blood lead concentrations of 25, 15, or 3 μg/dl …