Interferons (IFNs) are critical for anti-viral host defence. Type-1 and type-3 IFNs are typically
associated with early control of viral replication and promotion of inflammatory immune …

Abstract Type-1 and type-3 interferons (IFNs) are important for control of viral replication;
however, less is known about the role of Type-2 IFN (IFNγ) in anti-viral immunity. We …

While mRNA vaccine efficacy against the 2019 coronavirus disease (COVID-19) outbreak
remains high, research on antiviral innate immune responses in the early stages of infection …

Disease progression during SARS-CoV-2 infection is tightly linked to the fate of lung
epithelial cells, with severe cases of COVID-19 characterized by direct injury of the alveolar …

Summary Severe coronavirus disease 2019 (COVID-19) is characterized by overproduction
of immune mediators, but the role of interferons (IFNs) of the type I (IFN-I) or type III (IFN-III) …

Understanding early innate immune responses to coronavirus disease 2019 (COVID-19) is
crucial to developing targeted therapies to mitigate disease severity. Severe acute …

Coronavirus Disease 2019 (COVID-19), a respiratory illness caused by a novel coronavirus,
was first identified in the Hubei province of China in December 2019 and has now spread …

Interferon gamma (IFN-γ) may be potential adjuvant immunotherapy for COVID-19 patients.
In this work, we assessed gene expression profiles associated with the IFN-γ pathway in …

Type I interferons (IFNs) are our first line of defense against virus infection. Recent studies
have suggested the ability of SARS-CoV-2 proteins to inhibit IFN responses. Emerging data …

Bacille Calmette-Guérin (BCG) vaccination can confer non-specific protection against
heterologous pathogens. However, the underlying mechanisms remain mysterious. Here …