Spermatogenesis is a complex, multistep process that maintains male fertility and is
sustained by rare germline stem cells. Spermatogenic progression begins with …

Spermatogonial stem cells (SSCs) maintain spermatogenesis by self-renewal and
generation of spermatogonia committed to differentiation. Under certain in vitro conditions …

Human spermatogonia are target for exploration of adult stem cell characteristics and
potential source for the development of therapeutic applications. Almost 50 years ago, Yves …

This study was designed to isolate, characterize, and culture human spermatogonia. Using
immunohistochemistry on tubule sections, we localized GPR125 to the plasma membrane of …

Background Spermatogonial stem cells (SSCs) have the unique ability to undergo self-
renewal division. However, these cells are morphologically indistinguishable from …

Precise separation of spermatogonial stem cells (SSCs) from progenitor spermatogonia that
lack stem cell activity and are committed to differentiation remains a challenge. To …

Spermatogonial stem cells (SSCs) have the dual capacity to self-renew and differentiate into
progenitor spermatogonia that develop into mature spermatozoa. Here, we document that …

Continuous spermatogenesis in post-pubertal mammals is dependent on spermatogonial
stem cells (SSCs), which balance self-renewing divisions that maintain stem cell pool with …

Spermatogonial stem cells (SSCs) have unique characteristics in that they produce sperm
that transmit genetic information from generation to generation and they can be …

Spermatogonial stem cells (SSCs) are essential for the generation of sperm and have
potential therapeutic value for treating male infertility, which afflicts> 100 million men world …