The effects of proton pump inhibitors on the microbiome in young children

EI Levy, DM Hoang, Y Vandenplas - Acta Paediatrica, 2020 - Wiley Online Library
Aim The use of proton pump inhibitor (PPI) treatments are increasing among paediatric
patients worldwide. We aimed to review the effects of PPIs on the microbiome and its …

[HTML][HTML] The influence of proton pump inhibitors on the fecal microbiome of infants with gastroesophageal reflux—a prospective longitudinal interventional study

C Castellani, G Singer, K Kashofer… - Frontiers in Cellular …, 2017 - frontiersin.org
Proton pump inhibitors (PPIs) are the standard therapy for gastroesophageal reflux disease.
In adults, PPI treatment is associated with Clostridium difficile infections (CDI). In contrast to …

Proton pump inhibitors in children: the good, the bad, and the ugly

EA Pasman, B Ong, CP Witmer, CM Nylund - Current allergy and asthma …, 2020 - Springer
Abstract Purpose of Review The evidence supporting or contesting the prescription of proton
pump inhibitors (PPIs) for children and updates on side effects are reviewed. Recent …

Drugs in focus: proton pump inhibitors

MA Benninga, IJ Broekaert, F Gottrand… - Journal of pediatric …, 2021 - journals.lww.com
Proton pump inhibitors (PPIs) are amongst the most commonly prescribed drugs in infants
and children with the last decades witnessing a dramatic rise in their utilization. Although …

Proton pump inhibitors alter the composition of the gut microbiota

MA Jackson, JK Goodrich, ME Maxan, DE Freedberg… - Gut, 2016 - gut.bmj.com
Objective Proton pump inhibitors (PPIs) are drugs used to suppress gastric acid production
and treat GI disorders such as peptic ulcers and gastro-oesophageal reflux. They have been …

Side effects and complications of proton pump inhibitors: a pediatric perspective

CM Stark, CM Nylund - The Journal of pediatrics, 2016 - jpeds.com
Christopher M. Stark, MD, and Cade M. Nylund, MD Proton pump inhibitors (PPIs) are a
class of acid suppression medications that block gastric parietal cell acid production by …

[HTML][HTML] Proton pump inhibitors and dysbiosis: Current knowledge and aspects to be clarified

G Bruno, P Zaccari, G Rocco, G Scalese… - World journal of …, 2019 - ncbi.nlm.nih.gov
Proton pump inhibitors (PPIs) are common medications within the practice of
gastroenterology. These drugs, which act through the irreversible inhibition of the …

Systematic review: the effects of proton pump inhibitors on the microbiome of the digestive tract—evidence from next‐generation sequencing studies

L Macke, C Schulz, L Koletzko… - Alimentary …, 2020 - Wiley Online Library
Background Proton pump inhibitors (PPI) are widely used to treat acid‐related disorders of
the upper gastrointestinal tract. However, large observational studies have raised concerns …

[HTML][HTML] A narrative review on efficacy and safety of proton pump inhibitors in children

V Dipasquale, G Cicala, E Spina… - Frontiers in …, 2022 - frontiersin.org
Proton pump inhibitors (PPIs) are among the most prescribed drugs worldwide and include
omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole. Their use in …

Proton pump inhibitor use and risk of serious infections in young children

M Lassalle, M Zureik, R Dray-Spira - JAMA pediatrics, 2023 - jamanetwork.com
Importance Proton pump inhibitor (PPI) use may lead to infections through alteration of the
microbiota or direct action on the immune system. However, only a few studies were …