Air pollution consists of highly variable and complex mixtures recognized as major
contributors to morbidity and mortality worldwide. The vast number of chemicals, coupled …

Exposure to occupational and environmental contaminants is a major contributor to human
health problems. Inhalation of gases, vapors, aerosols, and mixtures of these can cause a …

Background The vision of a National Research Council (NRC) committee (the Committee on
Toxicity Testing and Assessment of Environmental Agents) for future toxicity testing involves …

Toxicology studies of adverse effects induced by inhaled chemicals are technically
challenging, due to the requirement of highly controlled experimental conditions needed to …

A new generation of scientific tools has emerged to rapidly measure signals from cells,
tissues, and organisms following exposure to chemicals. High-visibility efforts to apply these …

Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …

With 7 million deaths reported annually from air pollution alone, it is evident that adverse
effects of inhaled toxicant exposures remain a major public health concern in the 21st …

Background The US Environmental Protection Agency is facing large challenges in
managing environmental chemicals with increasingly complex requirements for assessing …

An evolving regulatory, scientific, and legislative landscape is driving a fundamental change
in how chemical safety decisions are made. As we move to implement changes, regulatory …

A comprehensive guide to assessing the health effects of environmental toxicants in
nonoccupational settings Now in a second edition, Environmental Toxicants: Human …