Machine learning-based label-free SERS profiling of exosomes for accurate fuzzy diagnosis of cancer and dynamic monitoring of drug therapeutic processes

X Diao, X Li, S Hou, H Li, G Qi, Y Jin - Analytical Chemistry, 2023 - ACS Publications
Exosomes are a class of extracellular vesicles secreted by cells, which can be used as
promising noninvasive biomarkers for the early diagnosis and treatment of diseases …

Identification of individual exosome‐like vesicles by surface enhanced raman spectroscopy

S Stremersch, M Marro, BE Pinchasik, P Baatsen… - Small, 2016 - Wiley Online Library
Exosome‐like vesicles (ELVs) are a novel class of biomarkers that are receiving a lot of
attention for the detection of cancer at an early stage. In this study the feasibility of using a …

Label‐Free Identification of Exosomes using Raman Spectroscopy and Machine Learning

U Parlatan, MO Ozen, I Kecoglu, B Koyuncu, H Torun… - Small, 2023 - Wiley Online Library
Exosomes, nano‐sized extracellular vesicles (EVs) secreted from cells, carry various cargo
molecules reflecting their cells of origin. As EV content, structure, and size are highly …

Ultrasensitive SERS-based detection of prostate cancer exosome using Cu2O–CuO@ Ag composite nanowires

J Ma, J Zhao, X Liu, C Gu, S Zeng… - Biosensors and …, 2024 - Elsevier
Exosome is a recently emerging cancer-associated biomarker for early diagnostic and
prognostic owing to their noninvasive, intrinsic stability, and representativeness of primitive …

Correlation between cancerous exosomes and protein markers based on surface-enhanced Raman spectroscopy (SERS) and principal component analysis (PCA)

H Shin, H Jeong, J Park, S Hong, Y Choi - ACS sensors, 2018 - ACS Publications
Exosomes, which are nanovesicles secreted by cells, are promising biomarkers for cancer
diagnosis and prognosis, based on their specific surface protein compositions. Here, we …

Label-free characterization of exosome via surface enhanced Raman spectroscopy for the early detection of pancreatic cancer

J Carmicheal, C Hayashi, X Huang, L Liu, Y Lu… - … , Biology and Medicine, 2019 - Elsevier
Pancreatic cancer is a highly lethal malignancy. Lack of early diagnostic markers makes
timely detection of pancreatic cancer a highly challenging endeavor. Exosomes have …

[HTML][HTML] Exosome detection via surface-enhanced Raman spectroscopy for cancer diagnosis

J Li, Y Li, P Li, Y Zhang, L Du, Y Wang, C Zhang… - Acta biomaterialia, 2022 - Elsevier
As nanoscale extracellular vesicles, exosomes are secreted by various cell types, and they
are widely distributed in multiple biological fluids. Studies have shown that tumor-derived …

[HTML][HTML] Surface-enhanced Raman scattering (SERS) spectroscopy for sensing and characterization of exosomes in cancer diagnosis

L Guerrini, E Garcia-Rico, A O'Loghlen, V Giannini… - Cancers, 2021 - mdpi.com
Simple Summary The distinct molecular and biological properties of exosomes, together
with their abundance and stability, make them an ideal target in liquid biopsies for early …

Exosome classification by pattern analysis of surface-enhanced Raman spectroscopy data for lung cancer diagnosis

J Park, M Hwang, BH Choi, H Jeong, J Jung… - Analytical …, 2017 - ACS Publications
Owing to the role of exosome as a cargo for intercellular communication, especially in
cancer metastasis, the evidence has been consistently accumulated that exosomes can be …

[HTML][HTML] Single test-based diagnosis of multiple cancer types using Exosome-SERS-AI for early stage cancers

H Shin, BH Choi, O Shim, J Kim, Y Park, SK Cho… - Nature …, 2023 - nature.com
Early cancer detection has significant clinical value, but there remains no single method that
can comprehensively identify multiple types of early-stage cancer. Here, we report the …