Regulation of Set1-COMPASS-mediated H3K4 methylation and Dot1-mediated H3K79
methylation by H2BK123 ubiquitination (H2Bub1) is an evolutionarily conserved trans …

The mechanism by which ubiquitination of histone H2B (H2Bub1) regulates H3-K4 and-K79
methylation and the histone H2A-H2B chaperone Spt16-mediated nucleosome dynamics …

The trans-histone regulatory cross talk between H2BK123 ubiquitination (H2Bub1) and
H3K4 and H3K79 methylation is not fully understood. In this study, we report that the …

Monoubiquitylation of histone H2B (H2Bub1), catalyzed by the heterodimeric ubiquitin
ligase complex RNF20/40, regulates multiple molecular and biological processes. The …

Functional centromeres are essential for proper cell division. Centromeres are established
largely by epigenetic processes resulting in incorporation of the histone H3 variant CENP-A …

Simple Summary Post-translational modifications (PTM) of histone tails represent
epigenomic regulation of the chromatin landscape, influencing gene expression and the …

The post-translational modification of histone proteins plays an important role in controlling
cell fate by directing essentially all DNA-associated nuclear processes. Misregulation and …

Highlights•Structures of Dot1L bound to ubiquitinated nucleosomes show the mechanism of
crosstalk between histone H3K79 methylation and H2B monoubiquitination.•Structural …

Monoubiquitination of histone H2B on Lys 123 (H2BK123ub) is a transient histone
modification considered to be essential for establishing H3K4 and H3K79 trimethylation by …

The COMPASS (complex of proteins associated with Set1) complex represents the prototype
of the SET1/MLL family of methyltransferases that controls gene transcription by H3K4 …