Unlike adult cardiomyocytes, neonatal cardiomyocytes can readily proliferate that
contributes to a transient regenerative potential after myocardial injury in mice. We have …

Aims Newborn mice and humans display transient cardiac regenerative potential that rapidly
declines postnatally. Patients who survive a myocardial infarction (MI) often develop chronic …

The neonatal mouse heart is capable of transiently regenerating after injury from postnatal
day (P) 0-7 and macrophages are found important in this process. However, whether …

The cardiovascular and immune systems undergo profound and intertwined alterations with
aging. Recent studies have reported that an accumulation of memory and terminally …

Heart regeneration is a promising strategy to prevent cardiac injury and protect against heart
failure. 1-3 Distinguishing from adult mammals, neonatal mouse heart can regenerate …

Aims Cardiac fibrosis is central to heart failure (HF), especially HF with preserved ejection
fraction (HFpEF), often caused by hypertension. Despite fibrosis causing diastolic …

Objective The present study analyzed the effect of CD4+ Forkhead box protein 3 negative
(Foxp3−) T-cells and Foxp3+ CD4+ T-cells on infarct size in a mouse myocardial ischemia …

The regeneration capacity of neonatal mouse heart is controversial. In addition, whether
epicardial cells provide a progenitor pool for de novo heart regeneration is incompletely …

Despite emerging data indicating a role for T cells in profibrotic cardiac repair and healing
after ischemia, little is known about whether T cells directly impact cardiac fibroblasts (CFBs) …

Myocardial infarction (MI) is a major condition causing heart failure (HF). After MI, the renin
angiotensin system (RAS) and its signalling octapeptide angiotensin II (Ang II) interferes with …