Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation

Y Jiang, Y Chen, Z Song, Z Tan, J Cheng - Advanced Drug Delivery …, 2021 - Elsevier
The recent outbreaks of infectious diseases caused by multidrug-resistant pathogens have
sounded a piercing alarm for the need of new effective antimicrobial agents to guard public …

Antimicrobial peptides under clinical investigation

HB Koo, J Seo - Peptide Science, 2019 - Wiley Online Library
Overuse of conventional antibiotics as well as the slow pace of new antibiotic drug
development leads to antimicrobial resistance (AMR). Because infections with multi‐drug …

[HTML][HTML] Discovery, optimization, and clinical application of natural antimicrobial peptides

AA Rodríguez, A Otero-González, M Ghattas… - Biomedicines, 2021 - mdpi.com
Antimicrobial peptides (AMPs) are widespread in multicellular organisms. These structurally
diverse molecules are produced as the first line of defense against pathogens such as …

Antimicrobial peptides: therapeutic potentials

SJ Kang, SJ Park, T Mishig-Ochir… - Expert review of anti …, 2014 - Taylor & Francis
The increasing appearance of multidrug-resistant pathogens has created an urgent need for
suitable alternatives to current antibiotics. Antimicrobial peptides (AMPs), which act as …

[HTML][HTML] Development and challenges of antimicrobial peptides for therapeutic applications

CH Chen, TK Lu - Antibiotics, 2020 - mdpi.com
More than 3000 antimicrobial peptides (AMPs) have been discovered, seven of which have
been approved by the US Food and Drug Administration (FDA). Now commercialized, these …

Advances on chemically modified antimicrobial peptides for generating peptide antibiotics

SB Rezende, KGN Oshiro, NGO Júnior… - Chemical …, 2021 - pubs.rsc.org
Antimicrobial peptides (AMPs) are pinpointed as promising molecules against antibiotic-
resistant bacterial infections. Nevertheless, there is a discrepancy between the AMP …

Membrane‐active small molecules: designs inspired by antimicrobial peptides

C Ghosh, J Haldar - ChemMedChem, 2015 - Wiley Online Library
Infectious diseases continue to be one of the major contributors to human morbidity. The
rapid rate at which pathogenic microorganisms have developed resistance against frontline …

Antimicrobial peptides: recent insights on biotechnological interventions and future perspectives

R Sinha, P Shukla - Protein and peptide letters, 2019 - ingentaconnect.com
With the unprecedented rise of drug-resistant pathogens, particularly antibiotic-resistant
bacteria, and no new antibiotics in the pipeline over the last three decades, the issue of …

[HTML][HTML] Antimicrobial peptides and proteins: from nature's reservoir to the laboratory and beyond

T Sarkar, M Chetia, S Chatterjee - Frontiers in Chemistry, 2021 - frontiersin.org
Rapid rise of antimicrobial resistance against conventional antimicrobials, resurgence of
multidrug resistant microbes and the slowdown in the development of new classes of …

Designing and optimizing new antimicrobial peptides: all targets are not the same

A Barreto-Santamaría, ME Patarroyo… - Critical Reviews in …, 2019 - Taylor & Francis
Because the resistance of microorganisms to the available antibiotics is a growing
healthcare problem worldwide, the search for new antimicrobial peptides (AMPs) that …