Many chronic diseases are marked by fibrosis, which is defined by an abundance of
activated fibroblasts and excessive deposition of extracellular matrix, resulting in loss of …

Fibrosis refers to the excessive deposition of extracellular matrix components in the
processes of wound repair or tissue regeneration after tissue damage. Fibrosis occurs in …

TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially
restricted generation of bioactive TGF-β from latent stores requires the cooperation of …

Transforming growth factor-β (TGF-β) is widely recognized as a core pathway of fibrosis.
Inhibition of TGF-β signaling may thus offer potential for antifibrotic therapies. Long-term …

Transforming growth factor β (TGF-β) is a central mediator of fibrogenesis. TGF-β is
upregulated and activated in fibrotic diseases and modulates fibroblast phenotype and …

Activation of TGF-β1 initiates a program of temporary collagen accumulation important to
wound repair in many organs. However, the outcome of temporary extracellular matrix …

Fibrosis is the abnormal accumulation of extracellular matrix proteins such as collagen and
fibronectin. Aging, injury, infections, and inflammation can cause different types of tissue …

Transforming growth factor-β (TGF-β) signaling is essential in embryo development and
maintaining normal homeostasis. Extensive evidence shows that TGF-β activation acts on …

The activation of fibroblasts is required for physiological tissue remodelling such as wound
healing. However, when the regulatory mechanisms are disrupted and fibroblasts remain …

Tissue fibrosis is a key factor leading to disability and death worldwide; however, thus far,
there are no approved treatments for fibrosis. Transforming growth factor (TGF)-β is a major …