Myriad of therapeutic drugs used in clinical practice have led to hepatotoxicity reporting
more than 1,100 pharmaceutical and chemical products with liver injury. Drug-induced liver …

The liver is the main organ where exogenous chemicals are metabolized and eventually
excreted. As a consequence, liver cells are exposed to significant concentrations of these …

Drug-induced liver injury is a ubiquitous issue in clinical settings and pharmaceutical
industry. Hepatotoxicity elicited by drugs may be intrinsic or idiosyncratic, both which are …

Liver is the principle organ for maintaining the body's internal environment. There is
currently no way to reimburse for the absence of liver function. Its major influence is on the …

Nowadays, drug-induced liver toxicity (DILT) is one of the main contributing factors to severe
liver disease. In the United States (US) alone, DILT is the cause of more than 50% of …

Drug-induced hepatotoxicity is a serious problem and has repeatedly led to the withdrawal
of a drug after successful launching. Although reactive metabolites (which are predictable) …

Despite recent advances in drug development technologies, some drugs continue to be
withdrawn from the market because of their late hepatotoxic effects. Drugs can cause liver …

Toxic injury occurs in the liver more often than any other organ. This can be attributed to the
fact that virtually all ingested substances that are absorbed are first presented to the liver …

This Clinical Liver Disease special series highlights the ever-growing, fascinating, and
challenging field of hepatotoxicity. Since Zimmerman's 1 initial characterization and …

Idiosyncratic drug-induced liver injury (DILI) is an important cause of morbidity and mortality
following drugs taken in therapeutic doses. Hepatotoxicity is a leading cause of attrition in …