The cell cycle is a collection of events by which cellular components such as genetic
materials and cytoplasmic components are accurately divided into two daughter cells. The …

Cell cycle progression is a tightly regulated process by which DNA replicates and cell
reproduces. The major driving force underlying cell cycle progression is the sequential …

The ubiquitin pathway plays a central role in the regulation of cell growth and cell
proliferation by controlling the abundance of key cell cycle proteins. Increasing evidence …

The ubiquitin proteasome system (UPS) has emerged from obscurity to be seen as a major
player in all regulatory processes in the cell. The concentrations of key proteins in diverse …

Dynamic modulation and posttranslational modification of proteins are tightly controlled
biological processes that occur in response to physiological cues. One such dynamic …

Accumulated evidence supports that the ubiquitin proteasome pathway (UPP) plays a
crucial role in protein metabolism implicated in the regulation of many biological processes …

The addition of ubiquitin to a target protein has long been implicated in the process of
degradation and is the primary mediator of protein turnover in the cell. Recently, however …

The covalent modification of proteins with ubiquitin is required for accurate cell division in all
eukaryotes. Ubiquitylation depends on an enzymatic cascade, in which E3 enzymes recruit …

Ever since the discovery of ubiquitin in 1975 [1], extensive research studies have shown that
the ubiquitin system is essential for maintaining homeostasis of the body by controlling a …

Proliferation is driven by an intricate machinery, the smooth operation of which is essential
for the development and survival of the organism. The central task of this machinery is to …