Short-chain fatty acids protect against high-fat diet–induced obesity via a PPARγ-dependent switch from lipogenesis to fat oxidation
G Den Besten, A Bleeker, A Gerding, K van Eunen… - Diabetes, 2015 - Am Diabetes Assoc
Short-chain fatty acids (SCFAs) are the main products of dietary fiber fermentation and are
believed to drive the fiber-related prevention of the metabolic syndrome. Here we show that …
believed to drive the fiber-related prevention of the metabolic syndrome. Here we show that …
Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) γ activators and pan-PPAR partial agonists
Thiazolidinediones (TZDs) act through peroxisome proliferator activated receptor (PPAR) γ
to increase insulin sensitivity in type 2 diabetes (T2DM), but deleterious effects of these …
to increase insulin sensitivity in type 2 diabetes (T2DM), but deleterious effects of these …
Short-chain fatty acids and inulin, but not guar gum, prevent diet-induced obesity and insulin resistance through differential mechanisms in mice
K Weitkunat, C Stuhlmann, A Postel, S Rumberger… - Scientific reports, 2017 - nature.com
The role of dietary fibre and short-chain fatty acids (SCFA) in obesity development is
controversially discussed. Here, we investigated how various types of dietary fibre and …
controversially discussed. Here, we investigated how various types of dietary fibre and …
Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3
H Shimizu, Y Masujima, C Ushiroda, R Mizushima… - Scientific reports, 2019 - nature.com
Fermented foods represent a significant portion of human diets with several beneficial
effects. Foods produced by bacterial fermentation are enriched in short-chain fatty acids …
effects. Foods produced by bacterial fermentation are enriched in short-chain fatty acids …
Regulation of energy metabolism by long-chain fatty acids
MT Nakamura, BE Yudell, JJ Loor - Progress in lipid research, 2014 - Elsevier
In mammals, excess energy is stored primarily as triglycerides, which are mobilized when
energy demands arise. This review mainly focuses on the role of long chain fatty acids …
energy demands arise. This review mainly focuses on the role of long chain fatty acids …
The role of short chain fatty acids in appetite regulation and energy homeostasis
Over the last 20 years there has been an increasing interest in the influence of the
gastrointestinal tract on appetite regulation. Much of the focus has been on the neuronal and …
gastrointestinal tract on appetite regulation. Much of the focus has been on the neuronal and …
Dietary fiber‐derived short‐chain fatty acids: A potential therapeutic target to alleviate obesity‐related nonalcoholic fatty liver disease
S Zhang, J Zhao, F Xie, H He, LJ Johnston… - Obesity …, 2021 - Wiley Online Library
Over the past several decades, increasing global prevalence of obesity‐related
nonalcoholic fatty liver disease (NAFLD) has been one of main challenges to human health …
nonalcoholic fatty liver disease (NAFLD) has been one of main challenges to human health …
Branched short-chain fatty acids modulate glucose and lipid metabolism in primary adipocytes
E Heimann, M Nyman, AK Pålbrink… - Adipocyte, 2016 - Taylor & Francis
Short-chain fatty acids (SCFAs), eg acetic acid, propionic acid and butyric acid, generated
through colonic fermentation of dietary fibers, have been shown to reach the systemic …
through colonic fermentation of dietary fibers, have been shown to reach the systemic …
Central and peripheral regulations mediated by short-chain fatty acids on energy homeostasis
The human gut microbiota influences obesity, insulin resistance, and the subsequent
development of type 2 diabetes (T2D). The gut microbiota digests and ferments nutrients …
development of type 2 diabetes (T2D). The gut microbiota digests and ferments nutrients …
High-fat diet reduces the formation of butyrate, but increases succinate, inflammation, liver fat and cholesterol in rats, while dietary fibre counteracts these effects
Introduction Obesity is linked to type 2 diabetes and risk factors associated to the metabolic
syndrome. Consumption of dietary fibres has been shown to have positive metabolic health …
syndrome. Consumption of dietary fibres has been shown to have positive metabolic health …
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