Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency

H Zeng, L Cheng, D Lu, S Fan, K Wang, L Xu… - Journal of …, 2023 - Springer
Background Spinal cord injury (SCI), which causes loss of sensory and motor function in the
body below the level of injury, is a devastating disease of the central nervous system. SCI …

Incomplete spinal cord injury reverses the level-dependence of spinal cord injury immune deficiency syndrome

J Hong, A Chang, Y Liu, J Wang… - International journal of …, 2019 - mdpi.com
Spinal cord injury (SCI) is associated with an increased susceptibility to infections, such as
pneumonia, which is the leading cause of death in these patients. This phenomenon is …

Immune dysfunction after spinal cord injury–A review of autonomic and neuroendocrine mechanisms

KA Rodgers, KA Kigerl, JM Schwab… - Current opinion in …, 2022 - Elsevier
Infections impair neurological outcome and increase mortality after spinal cord injury (SCI).
Emerging data show that pathogens more easily infect individuals with SCI because SCI …

Stress hormones collaborate to induce lymphocyte apoptosis after high level spinal cord injury

KM Lucin, VM Sanders… - Journal of …, 2009 - Wiley Online Library
Post‐traumatic immune suppression renders individuals with spinal cord injury (SCI)
susceptible to infection. Normally, proper immune function is regulated by collaboration …

The role of immune cells and associated immunological factors in the immune response to spinal cord injury

H Tang, Y Gu, L Jiang, G Zheng, Z Pan… - Frontiers in …, 2023 - frontiersin.org
Spinal cord injury (SCI) is a devastating neurological condition prevalent worldwide. Where
the pathological mechanisms underlying SCI are concerned, we can distinguish between …

Unbiased transcriptomic analyses reveal distinct effects of immune deficiency in CNS function with and without injury

D Luo, W Ge, X Hu, C Li, CM Lee, L Zhou, Z Wu… - Protein & …, 2019 - academic.oup.com
The mammalian central nervous system (CNS) is considered an immune privileged system
as it is separated from the periphery by the blood brain barrier (BBB). Yet, immune functions …

CCR7-mediated T follicular helper cell differentiation is associated with the pathogenesis and immune microenvironment of spinal cord injury-induced immune …

C Li, C Wu, G Xu, Y Liu, J Chen, J Zhang… - Frontiers in …, 2022 - frontiersin.org
Spinal cord injury-induced immune deficiency syndrome (SCI-IDS) is a disorder
characterized by systemic immunosuppression secondary to SCI that dramatically increases …

[HTML][HTML] Revealing potential spinal cord Injury biomarkers and Immune Cell infiltration characteristics in mice

L Cao, Q Li - Frontiers in Genetics, 2022 - frontiersin.org
Spinal cord injury (SCI) is a disabling condition with significant morbidity and mortality.
Currently, no effective SCI treatment exists. This study aimed to identify potential biomarkers …

[PDF][PDF] Development and validation of a differentiation-related signature based on single-cell RNA sequencing data of immune cells in spinal cord injury

J Shang, C Ma, H Ding, G Gu, J Zhang, M Wang… - Heliyon, 2023 - cell.com
Background After spinal cord injury (SCI), the native immune surveillance function of the
central nervous system is activated, resulting in a substantial infiltration of immune cells into …

Dominant mechanism in spinal cord injury-induced immunodeficiency syndrome (SCI-IDS): sympathetic hyperreflexia

P Yang, Z Bian, Z Song, C Yang, L Wang… - Reviews in the …, 2024 - degruyter.com
Clinical studies have shown that individuals with spinal cord injury (SCI) are particularly
susceptible to infectious diseases, resulting in a syndrome called SCI-induced …