Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency
H Zeng, L Cheng, D Lu, S Fan, K Wang, L Xu… - Journal of …, 2023 - Springer
Background Spinal cord injury (SCI), which causes loss of sensory and motor function in the
body below the level of injury, is a devastating disease of the central nervous system. SCI …
body below the level of injury, is a devastating disease of the central nervous system. SCI …
Incomplete spinal cord injury reverses the level-dependence of spinal cord injury immune deficiency syndrome
Spinal cord injury (SCI) is associated with an increased susceptibility to infections, such as
pneumonia, which is the leading cause of death in these patients. This phenomenon is …
pneumonia, which is the leading cause of death in these patients. This phenomenon is …
Immune dysfunction after spinal cord injury–A review of autonomic and neuroendocrine mechanisms
Infections impair neurological outcome and increase mortality after spinal cord injury (SCI).
Emerging data show that pathogens more easily infect individuals with SCI because SCI …
Emerging data show that pathogens more easily infect individuals with SCI because SCI …
Stress hormones collaborate to induce lymphocyte apoptosis after high level spinal cord injury
KM Lucin, VM Sanders… - Journal of …, 2009 - Wiley Online Library
Post‐traumatic immune suppression renders individuals with spinal cord injury (SCI)
susceptible to infection. Normally, proper immune function is regulated by collaboration …
susceptible to infection. Normally, proper immune function is regulated by collaboration …
The role of immune cells and associated immunological factors in the immune response to spinal cord injury
H Tang, Y Gu, L Jiang, G Zheng, Z Pan… - Frontiers in …, 2023 - frontiersin.org
Spinal cord injury (SCI) is a devastating neurological condition prevalent worldwide. Where
the pathological mechanisms underlying SCI are concerned, we can distinguish between …
the pathological mechanisms underlying SCI are concerned, we can distinguish between …
Unbiased transcriptomic analyses reveal distinct effects of immune deficiency in CNS function with and without injury
D Luo, W Ge, X Hu, C Li, CM Lee, L Zhou, Z Wu… - Protein & …, 2019 - academic.oup.com
The mammalian central nervous system (CNS) is considered an immune privileged system
as it is separated from the periphery by the blood brain barrier (BBB). Yet, immune functions …
as it is separated from the periphery by the blood brain barrier (BBB). Yet, immune functions …
CCR7-mediated T follicular helper cell differentiation is associated with the pathogenesis and immune microenvironment of spinal cord injury-induced immune …
C Li, C Wu, G Xu, Y Liu, J Chen, J Zhang… - Frontiers in …, 2022 - frontiersin.org
Spinal cord injury-induced immune deficiency syndrome (SCI-IDS) is a disorder
characterized by systemic immunosuppression secondary to SCI that dramatically increases …
characterized by systemic immunosuppression secondary to SCI that dramatically increases …
[HTML][HTML] Revealing potential spinal cord Injury biomarkers and Immune Cell infiltration characteristics in mice
L Cao, Q Li - Frontiers in Genetics, 2022 - frontiersin.org
Spinal cord injury (SCI) is a disabling condition with significant morbidity and mortality.
Currently, no effective SCI treatment exists. This study aimed to identify potential biomarkers …
Currently, no effective SCI treatment exists. This study aimed to identify potential biomarkers …
[PDF][PDF] Development and validation of a differentiation-related signature based on single-cell RNA sequencing data of immune cells in spinal cord injury
J Shang, C Ma, H Ding, G Gu, J Zhang, M Wang… - Heliyon, 2023 - cell.com
Background After spinal cord injury (SCI), the native immune surveillance function of the
central nervous system is activated, resulting in a substantial infiltration of immune cells into …
central nervous system is activated, resulting in a substantial infiltration of immune cells into …
Dominant mechanism in spinal cord injury-induced immunodeficiency syndrome (SCI-IDS): sympathetic hyperreflexia
P Yang, Z Bian, Z Song, C Yang, L Wang… - Reviews in the …, 2024 - degruyter.com
Clinical studies have shown that individuals with spinal cord injury (SCI) are particularly
susceptible to infectious diseases, resulting in a syndrome called SCI-induced …
susceptible to infectious diseases, resulting in a syndrome called SCI-induced …