SIRT1 mediates improvement of cardiac surgery-induced postoperative cognitive dysfunction via the TLR4/NF-κB pathway
J Shi, X Zou, K Jiang, F Wang - The World Journal of Biological …, 2020 - Taylor & Francis
Objectives Clinically, there is no effective therapy for postoperative cognitive dysfunction
(POCD). Inflammation after surgery is closely associated with POCD. Methods In this study …
(POCD). Inflammation after surgery is closely associated with POCD. Methods In this study …
[HTML][HTML] The role of SIRT1 in neuroinflammation and cognitive dysfunction in aged rats after anesthesia and surgery
J Yan, A Luo, J Gao, X Tang, Y Zhao… - American Journal of …, 2019 - ncbi.nlm.nih.gov
Postoperative cognitive dysfunction (POCD) is a neurological sequela of surgery and
anesthesia. It occurs with high incidence in the aged population. Neuroinflammation is …
anesthesia. It occurs with high incidence in the aged population. Neuroinflammation is …
[HTML][HTML] SIRT1 activation attenuates microglia-mediated synaptic engulfment in postoperative cognitive dysfunction
Y Sun, Y Wang, F Ye, V Cui, D Lin, H Shi… - Frontiers in Aging …, 2022 - frontiersin.org
Background Postoperative cognitive dysfunction (POCD) is a debilitating neurological
complication in surgical patients. Current research has focused mainly on microglial …
complication in surgical patients. Current research has focused mainly on microglial …
[HTML][HTML] SIRT3 enhances the protective role of Propofol in postoperative cognitive dysfunction via activating autophagy mediated by AMPK/mTOR pathway
S Li, Y Zhou, H Hu, X Wang, J Xu, C Bai… - Frontiers in Bioscience …, 2022 - imrpress.com
Background: Postoperative cognitive dysfunction (POCD) is a common complication after
surgery and anesthesia. In this study, we aimed to determine the neuroprotective …
surgery and anesthesia. In this study, we aimed to determine the neuroprotective …
[HTML][HTML] Sirtuin 3 protects against anesthesia/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation
Q Liu, YM Sun, H Huang, C Chen, J Wan… - Journal of …, 2021 - Springer
Background Postoperative cognitive dysfunction (POCD) is a very common complication that
might increase the morbidity and mortality of elderly patients after surgery. However, the …
might increase the morbidity and mortality of elderly patients after surgery. However, the …
SIRT3 activator honokiol ameliorates surgery/anesthesia‐induced cognitive decline in mice through anti‐oxidative stress and anti‐inflammatory in hippocampus
JS Ye, L Chen, YY Lu, SQ Lei… - CNS neuroscience & …, 2019 - Wiley Online Library
Aims Increasing evidence indicates that neuroinflammatory and oxidative stress play two
pivotal roles in cognitive impairment after surgery. Honokiol (HNK), as an activator of …
pivotal roles in cognitive impairment after surgery. Honokiol (HNK), as an activator of …
[HTML][HTML] Surgery-induced downregulation of hippocampal sirtuin-1 contributes to cognitive dysfunction by inhibiting autophagy and activating apoptosis in aged mice
QJ Fang, BH Chi, QC Lin, CM Huang… - American Journal of …, 2020 - ncbi.nlm.nih.gov
Objectives: Elderly patients often suffer from cognitive dysfunction following surgery.
However, the mechanisms underlying this phenomenon still remain unclear. This study …
However, the mechanisms underlying this phenomenon still remain unclear. This study …
Resveratrol mitigates hippocampal tau acetylation and cognitive deficit by activation SIRT1 in aged rats following anesthesia and surgery
J Yan, A Luo, R Sun, X Tang, Y Zhao… - Oxidative Medicine …, 2020 - Wiley Online Library
Postoperative cognitive dysfunction (POCD) is a sever postsurgical neurological
complication in the elderly population. As the global acceleration of population ageing …
complication in the elderly population. As the global acceleration of population ageing …
[PDF][PDF] Neuroprotective effect of CTRP3 overexpression against sevoflurane anesthesia-induced cognitive dysfunction in aged rats through activating AMPK/SIRT1 and …
LH Yang, YC Xu, W Zhang - European Review for Medical & …, 2020 - europeanreview.org
OBJECTIVE: To investigate the effects of C1q/tumor necrosis factor-related protein-3
(CTRP3) on postoperative cognitive dysfunction (POCD) and elucidate the potential …
(CTRP3) on postoperative cognitive dysfunction (POCD) and elucidate the potential …
Sirtuin 1 alleviates microglia-induced inflammation by modulating the PGC-1α/Nrf2 pathway after traumatic brain injury in male rats
X Chen, G Wei, D Li, Y Fan, Y Zeng, Z Qian, Z Jia… - Brain Research …, 2022 - Elsevier
Microglial activation and the subsequent inflammatory response play important roles in the
central nervous system after traumatic brain injury (TBI). Activation of the PGC-1α pathway is …
central nervous system after traumatic brain injury (TBI). Activation of the PGC-1α pathway is …
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