Endogenous labile iron pool-mediated free radical generation for cancer chemodynamic therapy

L Lin, S Wang, H Deng, W Yang, L Rao… - Journal of the …, 2020 - ACS Publications
Current chemodynamic therapy (CDT) primarily relies on the delivery of transition metal ions
with Fenton activity to trigger hydroxyl radical production from hydrogen peroxide. However …

Simultaneous Fenton‐like Ion Delivery and Glutathione Depletion by MnO2‐Based Nanoagent to Enhance Chemodynamic Therapy

LS Lin, J Song, L Song, K Ke, Y Liu, Z Zhou… - Angewandte …, 2018 - Wiley Online Library
Chemodynamic therapy (CDT) utilizes iron‐initiated Fenton chemistry to destroy tumor cells
by converting endogenous H2O2 into the highly toxic hydroxyl radical (. OH). There is a …

Tumor-specific expansion of oxidative stress by glutathione depletion and use of a fenton nanoagent for enhanced chemodynamic therapy

Q Chen, J Zhou, Z Chen, Q Luo, J Xu… - ACS applied materials & …, 2019 - ACS Publications
Amplifying intracellular oxidative stress effectively destroys cancer cells. In addition, iron-
mediated Fenton reaction converts endogenous H2O2 to produce hypertoxic hydroxyl …

Nano-Fenton reactors as a new class of oxidative stress amplifying anticancer therapeutic agents

B Kwon, E Han, W Yang, W Cho, W Yoo… - … applied materials & …, 2016 - ACS Publications
Cancer cells, compared to normal cells, are under oxidative stress associated with an
elevated level of reactive oxygen species (ROS) and are more vulnerable to oxidative stress …

Ultrasensitive Chemodynamic Therapy: Bimetallic Peroxide Triggers High pH‐Activated, Synergistic Effect/H2O2 Self‐Supply‐Mediated Cascade Fenton Chemistry

H Zhou, X Li, D Niu, Y Li, X Liu, C Li… - Advanced …, 2021 - Wiley Online Library
Recently, nanoparticle‐triggered in situ catalytic Fenton/Fenton‐like reaction is widely
explored for tumor‐specific chemodynamic therapy (CDT). However, despite the great …

Chemodynamic therapy: tumour microenvironment‐mediated Fenton and Fenton‐like reactions

Z Tang, Y Liu, M He, W Bu - Angewandte Chemie, 2019 - Wiley Online Library
Tailored to the specific tumour microenvironment, which involves acidity and the
overproduction of hydrogen peroxide, advanced nanotechnology has been introduced to …

Recent advances on endogenous/exogenous stimuli-triggered nanoplatforms for enhanced chemodynamic therapy

Q Sun, Z Wang, B Liu, F He, S Gai, P Yang… - Coordination Chemistry …, 2022 - Elsevier
In view of certain unique internalization features of the tumor microenvironment
(TME)(mainly including hypoxia, acidity and higher concentrations of H 2 O 2 and GSH) …

Amplification of tumor oxidative stresses with liposomal fenton catalyst and glutathione inhibitor for enhanced cancer chemotherapy and radiotherapy

Z Dong, L Feng, Y Chao, Y Hao, M Chen, F Gong… - Nano …, 2018 - ACS Publications
Amplification of intracellular oxidative stress has been found to be an effective strategy to
induce cancer cell death. To this end, we prepare a unique type of ultrasmall gallic acid …

Recent advances in enhancing reactive oxygen species based chemodynamic therapy

X Li, R Luo, X Liang, Q Wu, C Gong - Chinese Chemical Letters, 2022 - Elsevier
Chemodynamic therapy (CDT), defined as an in situ oxidative stress response catalyzed by
the Fenton or Fenton-like reactions to generate cytotoxic hydroxyl radicals (• OH) at tumor …

Activatable singlet oxygen generation from lipid hydroperoxide nanoparticles for cancer therapy

Z Zhou, J Song, R Tian, Z Yang, G Yu, L Lin… - Angewandte …, 2017 - Wiley Online Library
Reactive oxygen species (ROS)‐induced apoptosis is a widely practiced strategy for cancer
therapy. Although photodynamic therapy (PDT) takes advantage of the spatial–temporal …