Endogenous labile iron pool-mediated free radical generation for cancer chemodynamic therapy
Current chemodynamic therapy (CDT) primarily relies on the delivery of transition metal ions
with Fenton activity to trigger hydroxyl radical production from hydrogen peroxide. However …
with Fenton activity to trigger hydroxyl radical production from hydrogen peroxide. However …
Simultaneous Fenton‐like Ion Delivery and Glutathione Depletion by MnO2‐Based Nanoagent to Enhance Chemodynamic Therapy
Chemodynamic therapy (CDT) utilizes iron‐initiated Fenton chemistry to destroy tumor cells
by converting endogenous H2O2 into the highly toxic hydroxyl radical (. OH). There is a …
by converting endogenous H2O2 into the highly toxic hydroxyl radical (. OH). There is a …
Tumor-specific expansion of oxidative stress by glutathione depletion and use of a fenton nanoagent for enhanced chemodynamic therapy
Q Chen, J Zhou, Z Chen, Q Luo, J Xu… - ACS applied materials & …, 2019 - ACS Publications
Amplifying intracellular oxidative stress effectively destroys cancer cells. In addition, iron-
mediated Fenton reaction converts endogenous H2O2 to produce hypertoxic hydroxyl …
mediated Fenton reaction converts endogenous H2O2 to produce hypertoxic hydroxyl …
Nano-Fenton reactors as a new class of oxidative stress amplifying anticancer therapeutic agents
B Kwon, E Han, W Yang, W Cho, W Yoo… - … applied materials & …, 2016 - ACS Publications
Cancer cells, compared to normal cells, are under oxidative stress associated with an
elevated level of reactive oxygen species (ROS) and are more vulnerable to oxidative stress …
elevated level of reactive oxygen species (ROS) and are more vulnerable to oxidative stress …
Ultrasensitive Chemodynamic Therapy: Bimetallic Peroxide Triggers High pH‐Activated, Synergistic Effect/H2O2 Self‐Supply‐Mediated Cascade Fenton Chemistry
H Zhou, X Li, D Niu, Y Li, X Liu, C Li… - Advanced …, 2021 - Wiley Online Library
Recently, nanoparticle‐triggered in situ catalytic Fenton/Fenton‐like reaction is widely
explored for tumor‐specific chemodynamic therapy (CDT). However, despite the great …
explored for tumor‐specific chemodynamic therapy (CDT). However, despite the great …
Chemodynamic therapy: tumour microenvironment‐mediated Fenton and Fenton‐like reactions
Tailored to the specific tumour microenvironment, which involves acidity and the
overproduction of hydrogen peroxide, advanced nanotechnology has been introduced to …
overproduction of hydrogen peroxide, advanced nanotechnology has been introduced to …
Recent advances on endogenous/exogenous stimuli-triggered nanoplatforms for enhanced chemodynamic therapy
Q Sun, Z Wang, B Liu, F He, S Gai, P Yang… - Coordination Chemistry …, 2022 - Elsevier
In view of certain unique internalization features of the tumor microenvironment
(TME)(mainly including hypoxia, acidity and higher concentrations of H 2 O 2 and GSH) …
(TME)(mainly including hypoxia, acidity and higher concentrations of H 2 O 2 and GSH) …
Amplification of tumor oxidative stresses with liposomal fenton catalyst and glutathione inhibitor for enhanced cancer chemotherapy and radiotherapy
Amplification of intracellular oxidative stress has been found to be an effective strategy to
induce cancer cell death. To this end, we prepare a unique type of ultrasmall gallic acid …
induce cancer cell death. To this end, we prepare a unique type of ultrasmall gallic acid …
Recent advances in enhancing reactive oxygen species based chemodynamic therapy
X Li, R Luo, X Liang, Q Wu, C Gong - Chinese Chemical Letters, 2022 - Elsevier
Chemodynamic therapy (CDT), defined as an in situ oxidative stress response catalyzed by
the Fenton or Fenton-like reactions to generate cytotoxic hydroxyl radicals (• OH) at tumor …
the Fenton or Fenton-like reactions to generate cytotoxic hydroxyl radicals (• OH) at tumor …
Activatable singlet oxygen generation from lipid hydroperoxide nanoparticles for cancer therapy
Reactive oxygen species (ROS)‐induced apoptosis is a widely practiced strategy for cancer
therapy. Although photodynamic therapy (PDT) takes advantage of the spatial–temporal …
therapy. Although photodynamic therapy (PDT) takes advantage of the spatial–temporal …