The data reviewed in this article suggest that protons should no longer be considered simply
as an unwanted by-product of anaerobic respiration that results from either an accumulation …

In the late fifties and sixties Jancso published a series of papers on 'the peculiar
pharmacological effect of capsaicin Capsaicin or 8-methyl-N-vanillyi-6-nonenamide is the …

The selective excitant and neurotoxic action of capsaicin on vagal sensory neurons in the rat
has been investigated in vitro using three techniques: extracellular recording of compound …

Over the past several decades capsaicin, a natural product of certain species of red pepper,
has been found to have a broad range of physiological effects in adult animals. Recent …

We owe to N. Jancso'and his co-workers the discovery that animals treated with capsaicin
become, after an initial intense excitation of sensory neurons, unresponsive to noxious …

Capsaicin activates poorly myelinated primary afferent neurons, many of which are
polymodal nociceptors. Activation is accompanied by membrane depolarization and the …

After neonatal treatment of rats with capsaicin, the spinal cord, the spinal trigeminal nucleus
and spinal and trigeminal ganglia were analysed with immunohistochemistry using antisera …

Capsaicin applied locally to a coccygeal or saphenous nerve of rats was shown to block
impulse conduction in unmyelinated afferent nerve fibres. Shortly after application of …

Capsaicin produces pain by selectively activating polymodal nociceptive neurons. This
involves a membrane depolarization and the opening of a unique, cation-selective, ion …

The presence of the peptide substance P in small unmyelinated primary sensory neurons 5
appears to be related to the transmission of nociceptive impulses at the level of the spinal …