Mast cells are tissue resident, innate immune cells with heterogenous phenotypes tuned by
cytokines and other microenvironmental stimuli. Playing a protective role in parasitic …

Mast cells can function as effector and immunoregulatory cells in immunoglobulin E–
associated allergic disorders, as well as in certain innate and adaptive immune responses …

Mast cells have crucial roles in allergic and other inflammatory diseases. Preclinical
approaches provide circumstantial evidence for mast cell involvement in many diseases, but …

Mast cells are central players in immune surveillance and activation, positioned at the host–
environment interface. Understanding the signaling events controlling mast cell function …

Mast cells are best known for their potent effector functions in allergic disorders. In recent
years, however, mast cells have been identified to be involved in a surprisingly complex …

Mast cells regulate the immunological responses causing allergy and autoimmunity, and
contribute to the tumor microenvironment through generation and secretion of a broad array …

Mast cells are unique tissue-resident immune cells that express an array of receptors that
can be activated by several extracellular cues, including antigen–immunoglobulin E (IgE) …

Mast cells are currently recognized as effector cells in many settings beyond just allergic
reactions, including innate immunity, autoimmunity, chronic inflammatory disorders and …

Mast cells are well known for their role in allergic disease and have recently been implicated
in inflammatory disorders, including autoimmune arthritis, multiple sclerosis, and …

Mast cells are multifunctional cells that initiate not only IgE-dependent allergic diseases but
also play a fundamental role in innate and adaptive immune responses to microbial …