Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis

K Kiryluk, Y Li, S Sanna-Cherchi… - PLoS …, 2012 - journals.plos.org
IgA nephropathy (IgAN), major cause of kidney failure worldwide, is common in Asians,
moderately prevalent in Europeans, and rare in Africans. It is not known if these differences …

Genome-wide meta-analysis identifies three novel susceptibility loci and reveals ethnic heterogeneity of genetic susceptibility for IgA nephropathy

M Li, L Wang, DC Shi, JN Foo, Z Zhong… - Journal of the …, 2020 - journals.lww.com
Background Eighteen known susceptibility loci for IgAN account for only a small proportion
of IgAN risk. Methods Genome-wide meta-analysis was performed in 2628 patients and …

Genome-wide association study identifies susceptibility loci for IgA nephropathy

AG Gharavi, K Kiryluk, M Choi, Y Li, P Hou, J Xie… - Nature …, 2011 - nature.com
We carried out a genome-wide association study of IgA nephropathy, a major cause of
kidney failure worldwide. We studied 1,194 cases and 902 controls of Chinese Han …

A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy

XQ Yu, M Li, H Zhang, HQ Low, X Wei, JQ Wang… - Nature …, 2012 - nature.com
We performed a two-stage genome-wide association study of IgA nephropathy (IgAN) in
Han Chinese, with 1,434 affected individuals (cases) and 4,270 controls in the discovery …

Identification of new susceptibility loci for IgA nephropathy in Han Chinese

M Li, JN Foo, JQ Wang, HQ Low, XQ Tang… - Nature …, 2015 - nature.com
IgA nephropathy (IgAN) is one of the most common primary glomerulonephritis. Previously
identified genome-wide association study (GWAS) loci explain only a fraction of disease risk …

Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy

K Kiryluk, E Sanchez-Rodriguez, XJ Zhou, F Zanoni… - Nature …, 2023 - nature.com
IgA nephropathy (IgAN) is a progressive form of kidney disease defined by glomerular
deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney …

Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens

K Kiryluk, Y Li, F Scolari, S Sanna-Cherchi, M Choi… - Nature …, 2014 - nature.com
We performed a genome-wide association study (GWAS) of IgA nephropathy (IgAN), the
most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals …

Genetic heterogeneity in Italian families with IgA nephropathy: suggestive linkage for two novel IgA nephropathy loci

L Bisceglia, G Cerullo, P Forabosco, DD Torres… - The American Journal of …, 2006 - cell.com
IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide, but its etiologic
mechanisms are still poorly understood. Different prevalences among ethnic groups and …

HLA has strongest association with IgA nephropathy in genome-wide analysis

J Feehally, M Farrall, A Boland, DP Gale… - Journal of the …, 2010 - journals.lww.com
Demographic and family studies support the existence of a genetic contribution to the
pathogenesis of IgA nephropathy, but results from genetic association studies of candidate …

Pathogenesis of immunoglobulin A nephropathy: recent insight from genetic studies

K Kiryluk, J Novak, AG Gharavi - Annual review of medicine, 2013 - annualreviews.org
Recent genome-wide association studies (GWAS) have identified multiple susceptibility loci
for immunoglobulin A nephropathy (IgAN), the most common form of glomerulonephritis …