Abstract Multi-target Tyrosine Kinase Inhibitors (MTKIs) have drawn substantial attention in
tumor therapy. MTKIs could inhibit tumor cell proliferation and induce apoptosis by blocking …

Protein tyrosine kinases (PTKs) are closely related to tumor development and usually
participate in apoptosis, DNA repair, and cell proliferation by activating signaling pathways …

Nanotechnology is an important application in modern cancer therapy. In comparison with
conventional drug formulations, nanoparticles ensure better penetration into the tumor mass …

Tyrosine kinase inhibitors (TKIs), as an important class of chemotherapeutic drugs, induce
apoptosis by altering the path of the cellular signal, resulting in cell death. However, some …

Oral tyrosine kinase inhibitors (TKIs) against epidermal growth factor receptor (EGFR) family
have been introduced into the clinic to treat human malignancies for decades. Despite …

Recent progress in nanomedicine and targeted therapy brings new breeze into the field of
therapeutic applications of tyrosine kinase inhibitors (TKIs). These drugs are known for many …

Epidermal growth factor receptors (EGFRs) have potential to be considered as therapeutic
target for cancer treatment especially in cancer patients with overexpression of EGFR …

Therapeutic agents that inhibit a single target often cannot combat a multifactorial disease
such as cancer. Thus, multi-target inhibitors (MTIs) are needed to circumvent complications …

Cancer therapy faces many challenges, such as inadequate drug loading, low solubility,
leakage before reaching the target cells and killing healthy cells. Furthermore, severe side …

The therapeutic efficacy of anti-cancer nanomedicines is generally constrained due to
limited accumulation in the solid tumors. In this study, we developed a biomimetic nano …