Taken together, these findings demonstrate the critical roles of the MUC2 mucin and its
various O-glycans in the protection against colitis and colorectal cancer. Consistently …

All mucins are highly O-glycosylated by variable glycans depending on species, histoblood
group and organ. This makes the intestinal main mucin MUC2 non-degradable by the host …

MUC2 mucin is an important secretory protein found in the human gut. Recent studies
indicated that MUC2 mucin plays a role in the protection of gut barrier, the regulation of …

Objectives: In this study, we characterized colonic MUC2 mucin from a mucinous carcinoma
cell line and tried to find out carcinoma-associated alterations by comparing the results with …

Aim To determine the cellular location and expression of MUC17 mucin in specimens of
normal, inflamed and neoplastic colon. Methods Immunohistochemical analysis of human …

Colorectal cancer (CRC) exhibits complex pathogenesis via compromised intestinal
mucosal barrier. It is accepted that goblet cells secrete mucin which line the intestinal …

MUC4, a large transmembrane mucin normally expressed in the small and large intestine, is
differentially expressed during inflammatory and malignant conditions of the colon …

Mucins represent a family of glycoproteins characterized by repeat domains and a dense O-
glycosylation. During the last two decades, the gene and peptide structures of various …

Background The MUC2 mucin organizes the two mucus layers in the colon. This mucin
carries a large number of O-glycans that are assumed to be attachment sites for the …

Abstract Background/Aims: The MUC1 mucin distributes among a variety of epithelial tissues
(except the intestinal epithelia) and is often detectable in colorectal carcinoma tissues and …