Metformin is associated with higher incidence of acidosis, but not mortality, in individuals with COVID-19 and pre-existing type 2 diabetes

X Cheng, YM Liu, H Li, X Zhang, F Lei, JJ Qin, Z Chen… - Cell metabolism, 2020 - cell.com
The safety and efficacy of anti-diabetic drugs are critical for maximizing the beneficial
impacts of well-controlled blood glucose on the prognosis of individuals with COVID-19 and …

Metformin is associated with favorable outcomes in patients with COVID-19 and type 2 diabetes mellitus

Z Ma, N Patel, P Vemparala, M Krishnamurthy - Scientific reports, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is a new pandemic the entire world is facing
since December of 2019. Several risk factors are identified in developing severe disease …

Metformin and COVID-19: from cellular mechanisms to reduced mortality

AJ Scheen - Diabetes & metabolism, 2020 - Elsevier
Type 2 diabetes mellitus (T2DM) is associated with both poorer clinical outcomes during the
COVID-19 pandemic and an increased risk of death in such hospitalized patients. While the …

The effect of metformin on mortality and severity in COVID-19 patients with diabetes mellitus

W Yang, X Sun, J Zhang, K Zhang - Diabetes research and clinical practice, 2021 - Elsevier
Aim COVID-19 has spread globally with heavy impact on most countries and our therapeutic
strategies in COVID-19 patients with diabetes are still limited. Recently, some new …

Diabetes, metformin and the clinical course of Covid-19: outcomes, mechanisms and suggestions on the therapeutic use of metformin

CJ Bailey, M Gwilt - Frontiers in pharmacology, 2022 - frontiersin.org
Objectives: Pre-existing or new diabetes confers an adverse prognosis in people with Covid-
19. We reviewed the clinical literature on clinical outcomes in metformin-treated subjects …

Risk of metformin in patients with type 2 diabetes with COVID‐19: a preliminary retrospective report

Y Gao, T Liu, W Zhong, R Liu, H Zhou… - Clinical and …, 2020 - Wiley Online Library
The current outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐
2) infection has spread across the world. No specific antiviral agents have been adequately …

The effect of metformin consumption on mortality in hospitalized COVID-19 patients: a systematic review and meta-analysis

AA Lukito, R Pranata, J Henrina, MA Lim… - Diabetes & Metabolic …, 2020 - Elsevier
Background and aims Diabetes is one of the most common comorbidities, and it is
associated with poorer outcomes in patients with coronavirus disease 2019 (COVID-19) …

Metformin use is associated with a reduced risk of mortality in patients with diabetes hospitalised for COVID-19

JD Lalau, A Al-Salameh, S Hadjadj, T Goronflot… - Diabetes & …, 2021 - Elsevier
Aims Metformin exerts anti-inflammatory and immunosuppressive effects. We addressed the
impact of prior metformin use on prognosis in patients with type 2 diabetes hospitalised for …

[HTML][HTML] Metformin treatment was associated with decreased mortality in COVID-19 patients with diabetes in a retrospective analysis

P Luo, L Qiu, Y Liu, X Liu, J Zheng, H Xue… - The American journal …, 2020 - ncbi.nlm.nih.gov
Metformin was proposed to be a candidate for host-directed therapy for COVID-19. However,
its efficacy remains to be validated. In this study, we compared the outcome of metformin …

Association of metformin with mortality or ARDS in patients with COVID-19 and type 2 diabetes: A retrospective cohort study

N Jiang, Z Chen, L Liu, X Yin, H Yang, X Tan… - Diabetes research and …, 2021 - Elsevier
Aims To determine the association between metformin use and mortality and ARDS
incidence in patients with COVID-19 and type 2 diabetes. Methods This study was a multi …