[HTML][HTML] Multifactorial methods integrating haplotype and epistasis effects for genomic estimation and prediction of quantitative traits
Y Da, Z Liang, D Prakapenka - Frontiers in Genetics, 2022 - frontiersin.org
The rapid growth in genomic selection data provides unprecedented opportunities to
discover and utilize complex genetic effects for improving phenotypes, but the methodology …
discover and utilize complex genetic effects for improving phenotypes, but the methodology …
Accounting for epistasis improves genomic prediction of phenotypes with univariate and bivariate models across environments
E Vojgani, T Pook, JWR Martini, AC Hölker… - Theoretical and Applied …, 2021 - Springer
Abstract Key Message The accuracy of genomic prediction of phenotypes can be increased
by including the top-ranked pairwise SNP interactions into the prediction model. Abstract We …
by including the top-ranked pairwise SNP interactions into the prediction model. Abstract We …
Orthogonal estimates of variances for additive, dominance, and epistatic effects in populations
Genomic prediction methods based on multiple markers have potential to include
nonadditive effects in prediction and analysis of complex traits. However, most …
nonadditive effects in prediction and analysis of complex traits. However, most …
Mixed model methods for genomic prediction and variance component estimation of additive and dominance effects using SNP markers
Y Da, C Wang, S Wang, G Hu - PloS one, 2014 - journals.plos.org
We established a genomic model of quantitative trait with genomic additive and dominance
relationships that parallels the traditional quantitative genetics model, which partitions a …
relationships that parallels the traditional quantitative genetics model, which partitions a …
Detection of SNP epistasis effects of quantitative traits using an extended Kempthorne model
Epistasis effects (gene interactions) have been increasingly recognized as important genetic
factors underlying complex traits. The existence of a large number of single nucleotide …
factors underlying complex traits. The existence of a large number of single nucleotide …
Comparison of the Accuracy of Epistasis and Haplotype Models for Genomic Prediction of Seven Human Phenotypes
Z Liang, D Prakapenka, Y Da - Biomolecules, 2023 - mdpi.com
The accuracy of predicting seven human phenotypes of 3657–7564 individuals using global
epistasis effects was evaluated and compared to the accuracy of haplotype genomic …
epistasis effects was evaluated and compared to the accuracy of haplotype genomic …
Assumptions and properties of limiting pathway models for analysis of epistasis in complex traits
For most complex traits, results from genome-wide association studies show that the
proportion of the phenotypic variance attributable to the additive effects of individual SNPs …
proportion of the phenotypic variance attributable to the additive effects of individual SNPs …
[PDF][PDF] A unified approach to utilize phenotypic, full pedigree, andgenomic information for genetic evaluation
The concept of genomic selection (Meuwissen et al., 2001) generated great excitement in
the animal breeding community. With genomic information from SNP panels, one can …
the animal breeding community. With genomic information from SNP panels, one can …
Accurate prediction of genetic values for complex traits by whole-genome resequencing
T Meuwissen, M Goddard - Genetics, 2010 - academic.oup.com
Whole-genome resequencing technology has improved rapidly during recent years and is
expected to improve further such that the sequencing of an entire human genome sequence …
expected to improve further such that the sequencing of an entire human genome sequence …
Haplotype-based genome-wide prediction models exploit local epistatic interactions among markers
Genome-wide prediction approaches represent versatile tools for the analysis and
prediction of complex traits. Mostly they rely on marker-based information, but scenarios …
prediction of complex traits. Mostly they rely on marker-based information, but scenarios …