Seven-transmembrane receptors, which constitute the largest, most ubiquitous and most
versatile family of membrane receptors, are also the most common target of therapeutic …

Receptors have fascinated biologists for more than a century and they have fascinated me
for the entirety of my own research career. The seven transmembrane receptors, also known …

Seven-transmembrane receptors signal through nucleotide-binding proteins (G proteins)
into the cell. G proteins are membrane-associated proteins composed of three subunits …

The past few years have been an exciting period in the field of receptor biology as
remarkable similarities among various signal transduction systems have been revealed …

Heptahelical of serpentine receptors such as the adrenergic receptors are well known to
mediate their actions via heterotrimeric GTP-binding proteins. Likewise, receptors that …

The primary structure of G proteins as deduced from purified proteins and cloned subunits is
presented. When known, their functions are discussed, as are recent data on direct …

Receptors for hormones, neurotransmitters, drugs, sensory stimuli and many other agents
represent the gateway to cellular metabolism and activity. They regulate virtually all …

Pharmacologists have studied receptors for more than a century but a molecular
understanding of their properties has emerged only during the past 30–35 years. In this …

G protein-coupled, seven-transmembrane segment receptors (GPCRs or 7TM receptors),
with more than 1000 different members, comprise the largest superfamily of proteins in the …

Much regarding the engagement of the G 12 family of heterotrimeric G proteins (G 12 and G
13) by agonist-activated receptors remains unclear. For example, the identity of receptors …