In this Account, we describe the development of several diverse families of synthetic,
membrane-active amphiphiles that form pores and facilitate transport within membrane …

The X-ray crystal structures of biological ion channels are exquisitely complex, but not all
natural products capable of forming ion-conducting channels are equally elaborate …

The compelling chemical goal of modeling protein channel behavior has led to synthetic
compounds that are true ion channels. Although they largely lack the selectivity and …

The first synthetic ion channel, a cyclodextrin derivative, has been reported in 1982 by the
group of Tabushi in Tetrahedron Letters. 1 This occurred at a time when the rational design …

Natural ion channels are large protein complexes that regulate key functions of cells.
Supramolecular chemists have been able to take hints from Nature to design and prepare …

Conspectus Lipid bilayer membranes separate living cells from their environment.
Membrane proteins are responsible for the processing of ion and molecular inputs and …

An increasing number of synthetic compounds have been shown to facilitate ion and polar
molecule transport across bilayer membranes. Most notably, recent advances in anion …

The concept of channels has been with us more than a century. For half a century, biologists
have studied the remarkable workings of protein and peptide channels that permit various …

An artificial channel molecule 1 that mimics the shape and function of the ClC channel
selective pore was described. To facilitate the transport of chloride along a unimolecular …

The transport of alkali metal cations across vesicle bilayer membranes mediated by a series
of 21 synthetic transporters was investigated by a pH-stat technique. The relative activities of …