Protein persulfidation: Rewiring the hydrogen sulfide signaling in cell stress response

B He, Z Zhang, Z Huang, X Duan, Y Wang, J Cao… - Biochemical …, 2023 - Elsevier
The past few decades have witnessed significant progress in the discovery of hydrogen
sulfide (H 2 S) as a ubiquitous gaseous signaling molecule in mammalian physiology, akin …

Protein persulfidation: Recent progress and future directions

S Luo, C Kong, D Ye, X Liu, Y Wang… - Antioxidants & Redox …, 2023 - liebertpub.com
Significance: Hydrogen sulfide (H2S) is considered to be a gasotransmitter along with
carbon monoxide (CO) and nitric oxide (NO), and is known as a key regulator of …

Chemical Biology of H2S Signaling through Persulfidation

MR Filipovic, J Zivanovic, B Alvarez… - Chemical …, 2018 - ACS Publications
Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …

Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation

R Wedmann, C Onderka, S Wei, IA Szijártó… - Chemical …, 2016 - pubs.rsc.org
Hydrogen sulfide (H2S) has emerged as a signalling molecule capable of regulating several
important physiological functions such as blood pressure, neurotransmission and …

Emerging chemical biology of protein persulfidation

T Vignane, MR Filipovic - Antioxidants & Redox Signaling, 2023 - liebertpub.com
Significance: Protein persulfidation (the formation of RSSH), an evolutionarily conserved
oxidative posttranslational modification in which thiol groups in cysteine residues are …

[HTML][HTML] Cysteine trisulfide oxidizes protein thiols and induces electrophilic stress in human cells

CH Switzer, S Guttzeit, TR Eykyn, P Eaton - Redox Biology, 2021 - Elsevier
The cellular effects of hydrogen sulfide (H 2 S) signaling may be partially mediated by the
formation of alkyl persulfides from thiols, such as glutathione and protein cysteine residues …

Hydrogen sulfide biochemistry and interplay with other gaseous mediators in mammalian physiology

A Giuffrè, JB Vicente - Oxidative medicine and cellular longevity, 2018 - Wiley Online Library
Hydrogen sulfide (H2S) has emerged as a relevant signaling molecule in physiology, taking
its seat as a bona fide gasotransmitter akin to nitric oxide (NO) and carbon monoxide (CO) …

The role of protein persulfidation in brain aging and neurodegeneration

D Petrovic, E Kouroussis, T Vignane… - Frontiers in Aging …, 2021 - frontiersin.org
Hydrogen sulfide (H2S), originally considered a toxic gas, is now a recognized
gasotransmitter. Numerous studies have revealed the role of H2S as a redox signaling …

Role of hydrogen sulfide and polysulfides in neurological diseases: focus on protein S-persulfidation

HJ Sun, ZY Wu, XW Nie, JS Bian - Current …, 2021 - ingentaconnect.com
Hydrogen sulfide (H2S) and hydrogen polysulfides are recognized as important signaling
molecules that are generated physiologically in the body, including the central nervous …

The biological/physiological utility of hydropersulfides (RSSH) and related species: What is old is new again

JM Fukuto - Antioxidants & Redox Signaling, 2022 - liebertpub.com
Significance: Hydrogen sulfide (H2S) is reported to be an important mediator involved in
numerous physiological processes. H2S and hydropersulfides (RSSH) species are …